Extensive deep vein thrombosis as a complication of testicular cancer treated with the BEP protocol (bleomycin, etoposide and cisplatin): case report.

Abstract

CONTEXT:

There are no reports in the literature of massive deep venous thrombosis (DVT) associated with cisplatin, bleomycin and etoposide (BEP) cancer treatment.

CASE REPORT:

The patient was a 18-year-old adolescent with a nonseminomatous germ cell tumor of the right testicle, with the presence of pulmonary, liver, and massive retroperitoneal metastases. Following radical orchiectomy, the patient started chemotherapy according to the BEP protocol (without routine prophylaxis for DVT). On day 4 of the first cycle, massive DVT was diagnosed, extending from both popliteal veins up to the thoracic segment of the inferior vena cava. Thrombolytic therapy with streptokinase was immediately started. On day 2 of thrombolytic therapy, the patient developed acute renal failure, due to extension of the thrombosis to the renal veins. Streptokinase was continued for six days and the outcome was remarkably favorable.

• Authors: Max Senna Mano, José Luiz Miranda Guimarães, Sören Franz Marian Chicata Sutmöller, André Borba Reiriz, Christian Sandor Svend Chicata Sutmöller, Angelo Di Leo
• Journal: Sao Paulo medical journal = Revista paulista de medicina (Sao Paulo Med J) Vol. 124 Issue 6 Pg. 343-5 (Nov 07 2006) ISSN: 1516-3180 [Print] Brazil
• PMID: 17322957 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Fibrinolytic Agents
• Bleomycin
• Etoposide
• Streptokinase
• Cisplatin

Topics

• Adult
• Antineoplastic Agents (adverse effects, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects, therapeutic use)
• Bleomycin (administration & dosage, adverse effects)
• Cisplatin (administration & dosage, adverse effects)
• Etoposide (administration & dosage, adverse effects)
• Fibrinolytic Agents (therapeutic use)
• Humans
• Male
• Streptokinase (therapeutic use)
• Testicular Neoplasms (drug therapy)
• Ultrasonography, Doppler, Duplex
• Vena Cava, Inferior (diagnostic imaging)
• Venous Thrombosis (chemically induced, diagnostic imaging, therapy)