Testicular Neoplasms (Testicular Cancer)

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2420 relevant articles (137 outcomes, 245 trials/studies) found for this Disease

Description: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.

Also Known As:

Testicular Cancer; Cancer of the Testis; Neoplasms, Testicular; Neoplasms, Testis; Testis Neoplasms; Tumor of Rete Testis; Cancer, Testicular; Cancer, Testis; Cancers, Testicular; Cancers, Testis; Neoplasm, Testicular; Neoplasm, Testis; Rete Testis Tumor; Rete Testis Tumors; Testicular Cancers; Testicular Neoplasm; Testis Cancers; Testis Neoplasm; Testis Tumor, Rete; Testis Tumors, Rete; Cancer of Testis; Testis Cancer

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Testicular Neoplasms (Testicular Cancer)
3.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
4.	Lymphoma (Lymphomas)
5.	Breast Neoplasms (Breast Cancer)

Experts

1.	Old, Lloyd J: 21 articles (01/2008 - 04/2002)
2.	Jungbluth, Achim A: 19 articles (10/2008 - 10/2002)
3.	Chen, Yao-Tseng: 15 articles (06/2008 - 04/2002)
4.	Simpson, Andrew J G: 9 articles (01/2008 - 11/2004)
5.	Spagnoli, Giulio C: 9 articles (01/2007 - 09/2002)
6.	Bokemeyer, C: 8 articles (09/2008 - 09/2000)
7.	Ritter, Gerd: 8 articles (02/2007 - 04/2002)
8.	Scanlan, Matthew J: 8 articles (05/2005 - 04/2002)
9.	German Testicular Cancer Study Group: 7 articles (06/2008 - 05/2003)
10.	Caballero, Otavia L: 7 articles (06/2008 - 11/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Testicular Neoplasms:

1.	Cisplatin (Platino)FDA LinkGeneric 01/01/1992 - "The descriptive epidemiological study of the data of the literature reveals a considerable improvement in the prognosis of testicular cancers, particularly since the introduction of cisplatin in the 1980. " 01/01/1992 - "The descriptive epidemiological study of the data of the literature reveals a considerable improvement in the prognosis of testicular cancers, particularly since the introduction of cisplatin in the 1980. " 08/30/2002 - "Cisplatin is an effective agent for the treatment of testicular cancer. " 09/01/2000 - "As a result of the introduction of effective cisplatin-based chemotherapeutic regimens into the clinical routine, even patients with metastatic testicular cancer at initial diagnosis can be cured of their disease. " 01/01/1997 - "A phase II study has shown interesting activity when used in combination with cisplatin in cisplatin-refractory testicular cancer patients. " Order ALL the reference details at left...
2.	Etoposide (VP 16)FDA LinkGeneric 03/01/1986 - "[Complete remission obtained in advanced testicular cancer treated by etoposide (NK-171)]" 04/01/1989 - "The impact of etoposide on prolonging survival in lung and testicular cancer is addressed, and studies evaluating the pharmacodynamics of etoposide are described. " 06/01/2009 - "Since testicular cancer primarily affects young males, we used pubertal rats (21 days old) as a model to determine different apoptotic parameters after etoposide treatment in healthy testes. " 06/01/2009 - "Etoposide is widely used in the treatment of patients with testicular cancer. " 03/01/1996 - "PVB treatment for testicular cancer is not followed by increased leukaemia risk, but modern etoposide-containing regimens do confer excess risk, of which the magnitude at conventional drug doses is not yet well known. " Order ALL the reference details at left...
3.	Bleomycin (Blenoxane)FDA LinkGeneric 11/01/2003 - "Several clinical trials have focused on eliminating bleomycin from the regimen or reducing the bleomycin dose for testicular cancer patients with good prognosis. " 04/10/2008 - "Bleomycin in testicular cancer: will pharmacogenomics improve treatment regimens?" 05/01/2005 - "Can bleomycin toxicity in the treatment of testis cancer be batch related?" 02/01/2003 - "Here we discuss our advice to a young male patient, who was successfully treated with bleomycin for testicular cancer, concerning the safety to return to scuba diving. " 01/01/2003 - "PATIENTS AND METHODS: From our prospectively collected testicular cancer research database, we reviewed 835 patients treated at the Royal Marsden NHS Trust (Sutton, UK) with bleomycin-containing regimens for germ-cell tumours between January 1982 and December 1999, to identify those with BPT. " Order ALL the reference details at left...
4.	PlatinumIBA 10/01/1994 - "Pharmacokinetic and toxicity data from 23 patients with ovarian or testicular cancer were combined with published values from four other centers and the relationships between plasma clearance of ultrafilterable platinum and GFR, and between percentage reduction in platelet count and area under the plasma platinum curve were determined. " 05/01/2001 - "Patients with relapsed/ refractory testicular cancer benefit most from ABMT if they have platinum-sensitive disease in first relapse. " 12/10/1999 - "Platinum organ toxicity and possible prevention in patients with testicular cancer." 01/01/1995 - "We examined urinary platinum concentrations in 23 men at 150-3022 days after anticancer treatment for testicular neoplasm. " 10/21/1982 - "Cis-(diammine-dichloro-) platinum containing polychemotherapy combined with surgery has markedly improved the prognosis of cancer of the testis even in the metastatic stage. " Order ALL the reference details at left...
5.	Ifosfamide FDA LinkGeneric 04/01/1990 - "Studies currently under way should determine the optimal use of ifosfamide against testicular neoplasms, including its possible role as part of initial induction therapy." 05/01/1994 - "In both human testicular cancer cell lines, H 12.1 and 2102 EP, ifosfamide demonstrated anti-tumour activity as a single agent. " 04/01/1990 - "Ifosfamide in testicular cancer." 03/01/1989 - "Ifosfamide approved for treatment of testicular cancer." 02/01/1989 - "Ifosfamide in testicular cancer: the Indiana University experience." Order ALL the reference details at left...
6.	Vinblastine (Vinblastine Sulfate)FDA Link 08/01/1988 - "The clinical pharmacokinetics of vinblastine administered by continuous 5-day infusion (3 mg/m2/day) was studied in 12 patients with primary testicular cancer. " 08/01/1988 - "The correlation of vinblastine pharmacokinetics to toxicity in testicular cancer patients." 06/01/1986 - "PVB with a 0.2-mg/kg vinblastine dosage is very effective and well-tolerated therapy in selected good-risk patients with disseminated germinal testis cancer." 05/01/1970 - "Vinblastine in the management of testicular cancer." 09/01/1981 - "Our third-generation study, done in conjunction with the Southeastern Cancer Study Group, tested the hypothesis of whether maintenance vinblastine was necessary to ensure optimal cure rates in disseminated testicular cancer. " Order ALL the reference details at left...
7.	Carboplatin (JM8)FDA LinkGeneric 04/01/1989 - "Recent evidence indicates that carboplatin may be useful in the treatment of various forms of testicular cancer. " 09/01/1997 - "Data from testicular cancer also strongly supports an AUC-response relationship with an increased number of treatment failures with carboplatin AUCs < 5 to 6 mg/ml.min. Given the AUC-effect relationships described above a number of studies have been performed to develop models to describe the relationship between both dose and AUC and dose and platelet nadir. " 10/01/1994 - "In potentially curative settings (eg, testicular cancer) and in combination with radiation, results obtained with carboplatin are less clear and further study will be required." 08/01/2009 - "For adjuvant carboplatin, longer follow-up data are needed to better define survival, long-term toxicities, frequency of second primary testicular cancers, quality of life, and cost to the healthcare system." 04/01/1989 - "Use of carboplatin in the treatment of testicular cancer." Order ALL the reference details at left...
8.	alpha-Fetoproteins (AFP)IBA 11/01/1987 - "We attempted to determine the efficacy of basic fetoprotein as a marker in testicular cancer. " 01/01/2008 - "A 42-year-old man, with a clinical history of right testicular cancer, was referred to our hospital with elevated serum alpha-fetoprotein (AFP) level. " 08/23/1999 - "We investigated a sensitive method to detect malignant cells in the peripheral blood and peripheral blood stem cells of patients with testicular cancer using nested, reverse transcription-polymerase chain reaction (RT-PCR) to measure alpha-fetoprotein gene expression. " 01/01/1992 - "Detection of serum and cellular AFP and hCG has made a significant contribution in understanding and management of testicular cancer. " 11/01/1987 - "Histological localization of basic fetoprotein in testicular cancer tissue was demonstrated immunohistochemically. " Order ALL the reference details at left...
9.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 09/01/1974 - "High-dose cyclophosphamide (NSC-26271) for the treatment of metastatic testicular neoplasms." 09/01/1991 - "Two followed treatment of malignancy--one by radiation for testicular cancer and one by cyclophosphamide for a lymphoma. " 06/01/1981 - "Two patients with metastatic embryonal testicular cancer achieved complete remission receiving a vinblastine-cyclophosphamide combination chemotherapy. " 06/01/1996 - "Because of this, and because of the agent's proven synergism in combination chemotherapy for recurrent testicular cancer and its relative non-myelosuppressive qualities (compared with cyclophosphamide), the incorporation of ifosfamide into combination chemotherapy for SCLC was rational. " 01/01/1989 - "High dose chemotherapy including vepeside, cyclophosphamide and carboplatin with autologous bone marrow transplantation in one case of chemoresistant testicular cancer." Order ALL the reference details at left...
10.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 12/01/1989 - "Reduced metabolic clearance of acidic variants of human choriogonadotropin from patients with testicular cancer." 08/01/1981 - "Improved human chorionic gonadotropin detection with carboxyl-terminal radioimmunoassay of the beta subunit on concentrated 24-hour urine in patients with testicular cancer." 11/01/2008 - "BACKGROUND: We studied whether measurement of the free beta subunit of human chorionic gonadotropin (hCGbeta) in serum offers additional diagnostic information compared to determination of intact hCG alone in testicular cancer. " 11/01/2008 - "Free beta-subunit of human chorionic gonadotropin in serum is a diagnostically sensitive marker of seminomatous testicular cancer." 03/01/2008 - "PURPOSE: The finding of an unexplainable persistent low level of serum human chorionic gonadotropin in the management of testicular cancer sometimes misleads physicians. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 04/01/2003 - "Most patients we see now as "cured" of testicular cancer were treated either with chemotherapy or with radiotherapy. " 02/01/1988 - "The testicular cancer has been most effectively treated with the combined chemotherapy. " 11/01/1995 - "In patients with refractory nonseminomatous testicular cancer there have been a number of studies performed with high-dose chemotherapy showing a 15% complete and prolonged remission. " 10/01/2004 - "The risk of recurrent testicular cancer depends on primary therapy and efficacy of it; these results indicate a limited role for follow-up in pathological stage II nonseminoma patients adjuvantly treated with chemotherapy and in histologically confirmed complete responders after chemotherapy. " 10/01/2002 - "In order to save valuable resources, CXR can be omitted from the follow-up schedule after chemotherapy for marker-positive non-seminomatous testicular cancer in complete remission." Order ALL the reference details at left...
2.	Combination Drug Therapy (Combination Chemotherapy) 12/01/1984 - "[Case report of a non-seminomatous testicular neoplasm indicating marked efficacy of a combination chemotherapy of VBL, ACTD, BLM, CDDP and EX (VAB-4 combination therapy)]" 01/01/1984 - "Presently, however, any clinical study comparing single agent activity in untreated patients with testicular cancer would meet ethical restrictions since combination chemotherapy affords cures in 30-80% of all cases. " 01/01/2003 - "Disseminated testicular cancer, once uniformly fatal, now has a cure rate of more than 80% with combination chemotherapy. " 06/01/2000 - "OBJECTIVES: To investigate the impact of polychemotherapy on cellular immunity in patients with testicular cancer. " 01/01/1998 - "He had been treated with 4 courses of combination chemotherapy for his testicular cancer. " Order ALL the reference details at left...
3.	Lymph Node Excision (Lymph Node Dissection) 04/01/2003 - "CONCLUSIONS: Repeat retroperitoneal lymph node dissection is safe and effective in the majority of patients with recurrent or residual retroperitoneal masses after initial multimodality treatments for metastatic testis cancer. " 12/01/1994 - "We recorded the SSR to check the efficacy of "nerve-sparing" technique in surgery of the sympathetic retroperitoneal postganglionic fibres following lymphadenectomy in nonseminomatous testis cancer. " 10/01/1994 - "The efficacy of laparoscopic retroperitoneal lymph node dissection compared with standard techniques and determination of its role in patients with testicular cancer will require longer followup in larger groups of patients." 12/01/2008 - "METHODS: A MEDLINE search was performed using the terms "laparoscopy" or "laparoscopic," "retroperitoneal lymph node dissection" or "RPLND," and "testicular neoplasms." Articles were included on the basis of study design and content. " 03/01/2004 - "The purpose of the study was to update the current status of laparoscopic retroperitoneal lymph node dissection in the treatment of clinical Stage I nonseminomatous germ cell testicular cancer. " Order ALL the reference details at left...
4.	Adjuvant Chemotherapy 04/01/2001 - "Adjuvant chemotherapy in stage I and stage II testicular cancer." 08/01/1998 - "Stage II nonseminomatous testis cancer: the roles of primary and adjuvant chemotherapy." 11/01/1997 - "[Treatment of stage I nonseminomatous testicular cancer with one cycle of adjuvant chemotherapy]" 10/01/1997 - "Adjuvant chemotherapy for testicular cancer." 12/01/1996 - "In stage I non-seminomatous testicular cancer, the decision between surveillance and adjuvant chemotherapy rests heavily upon the valuation of quality of life. " Order ALL the reference details at left...
5.	Salvage Therapy 08/01/1996 - "Early salvage therapy or first-line therapy using HDCT is under investigation to improve treatment efficacy of the refractory or poor-risk testicular cancer. " 08/01/1996 - "[Salvage therapy for refractory testicular cancer]" 04/01/1992 - "Salvage therapy in recurrent testicular cancer." 01/01/1989 - "Salvage therapy in refractory and relapsing testicular cancer." 08/15/1996 - "Patients were treated with aggressive combination chemotherapy consisting of alternating regimens similar to those used as testis cancer salvage therapy. " Order ALL the reference details at left...

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