Abstract | BACKGROUND: METHODS: Serum MCP-1 levels and expression of monocyte adhesion molecules in 51 type 1 diabetic patients with and without diabetic nephropathy were compared with matched 15 healthy control subjects. Concentrations of serum MCP-1 were determined by enzyme-linked immunosorbent assays whereas monocyte expression of adhesion molecules Mac-1 and LFA-1 was measured by flow cytometry. RESULTS: Serum MCP-1 levels and expression of Mac-1, but not LFA-1, were significantly higher in diabetic patients compared with controls. The mean serum MCP-1 level was 137.2 +/- 71.4 pg/mL in control patients, whereas it was 246.2 +/- 114.9 pg/ml in diabetic patients (p = 0.002). Serum MCP-1 levels were positively correlated with HbA1c and plasma fasting glucose levels. There was no difference in serum levels of MCP-1 and expression of monocyte adhesion molecules between type 1 diabetic patients with and without diabetic nephropathy. CONCLUSIONS: In type 1 diabetic patients, the levels of circulating MCP-1 concentration and expression of Mac-1 is mostly influenced by glycemic control rather than the existence of diabetic nephropathy.
|
Authors | Sinem Kiyici, Erdinc Erturk, Ferah Budak, Canan Ersoy, Ercan Tuncel, Cevdet Duran, Barbaros Oral, Deniz Sigirci, Sazi Imamoglu |
Journal | Archives of medical research
(Arch Med Res)
Vol. 37
Issue 8
Pg. 998-1003
(Nov 2006)
ISSN: 0188-4409 [Print] United States |
PMID | 17045117
(Publication Type: Journal Article)
|
Chemical References |
- Cell Adhesion Molecules
- Chemokine CCL2
- Lymphocyte Function-Associated Antigen-1
|
Topics |
- Adult
- Cell Adhesion Molecules
(analysis, blood, metabolism)
- Chemokine CCL2
(analysis, blood, metabolism)
- Diabetes Mellitus, Type 1
(complications, metabolism)
- Diabetic Nephropathies
(diagnosis, metabolism)
- Female
- Humans
- Lymphocyte Function-Associated Antigen-1
(analysis, blood, metabolism)
- Male
- Monocytes
(chemistry)
- Up-Regulation
|