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Lymphocyte Function-Associated Antigen-1 (LFA-1)

An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Also Known As:
LFA-1; Integrin alphaLbeta2; Antigen-1, Lymphocyte Function-Associated; Lymphocyte Function Associated Antigen 1; alphaLbeta2, Integrin; Leukocyte Function Associated Antigen-1
Networked: 845 relevant articles (18 outcomes, 81 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ballantyne, Christie M: 7 articles (04/2008 - 01/2002)
2. Thorlacius, Henrik: 6 articles (01/2019 - 12/2002)
3. Siahaan, Teruna J: 6 articles (02/2010 - 03/2002)
4. Tremblay, Michel J: 6 articles (11/2009 - 02/2002)
5. Norenberg, Jeffrey P: 5 articles (11/2020 - 10/2006)
6. Ley, Klaus: 5 articles (08/2012 - 01/2002)
7. Wagner, Carston R: 4 articles (01/2020 - 10/2006)
8. Hammer, Daniel A: 4 articles (10/2019 - 11/2005)
9. Kachlany, Scott C: 4 articles (03/2015 - 06/2010)
10. Dong, Cheng: 4 articles (01/2015 - 09/2005)

Related Diseases

1. Inflammation (Inflammations)
2. Neoplasms (Cancer)
3. Infections
4. Psoriasis (Pustulosis Palmaris et Plantaris)
5. Autoimmune Diseases (Autoimmune Disease)

Related Drugs and Biologics

1. Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
2. Monoclonal Antibodies
3. Integrin alpha4beta1 (VLA-4)
4. Antibodies
5. Lymphocyte Function-Associated Antigen-1 (LFA-1)
6. Integrins
7. leukotoxin
8. Membrane Glycoproteins (Membrane Glycoprotein)
9. Magnesium
10. Ophthalmic Solutions (Eye Drops)

Related Therapies and Procedures

1. Transplantation
2. Heterologous Transplantation (Xenotransplantation)
3. Therapeutics
4. Ligation
5. Aftercare (After-Treatment)