Synergistic effect of interleukin-6 promoter (IL6 -634C/G) and intercellular adhesion molecule-1 (ICAM-1 469K/E) gene polymorphisms on the risk of endometriosis in Japanese women.
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| Abstract | PROBLEM:
Endometriosis is an immune-related, chronic inflammatory disease with a polygenic predisposition. The aim of this study was to investigate whether the interleukin-6 (IL-6) gene promoter region polymorphism (-634C/G) and the intercellular adhesion molecule-1 (ICAM-1) gene 469K/E polymorphism are responsible in part for the genetic susceptibility to endometriosis. METHODS OF STUDY: The IL-6 -634C/G and ICAM-1 469K/E genotypes were determined in 202 patients with endometriosis and 236 control women by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: There were no differences in the IL-6 -634C/G or the ICAM-1 469K/E genotypes and allele frequencies between control women and endometriosis patients collectively, or between control women and each clinical subgroup of endometriosis patients. Interestingly, the frequency of ICAM-1 EE homozygotes who concomitantly carried the IL-6 -634G allele was significantly higher in patients with endometriosis (chi(2) = 6.458, P = 0.0396, d.f. = 2). CONCLUSION: Our results suggest that the IL-6 -634C/G and ICAM-1 469K/E polymorphisms synergistically affect the susceptibility for endometriosis in the Japanese population.
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| Authors | Jo Kitawaki, Miyo Kiyomizu, Hiroshi Obayashi, Mitsuhiro Ohta, Hiroaki Ishihara, Goji Hasegawa, Naoto Nakamura, Toshikazu Yoshikawa, Hideo Honjo |
| Journal | American journal of reproductive immunology (New York, N.Y. : 1989) (Am J Reprod Immunol) Vol. 56 Issue 4 Pg. 267-74 (Oct 2006) ISSN: 1046-7408 [Print] Denmark |
| PMID | 16938116 (Publication Type: Journal Article) |
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