Cerebroprotective effect of a new taurine derivative during cerebral ischemia.

Abstract

A new taurine derivative chlorohydrate-N-isopropylamide-2-(1-phenylethyl)aminoethanesulfonic acid normalized energy metabolism, inhibited lipid peroxidation, and reactivated antioxidant enzymes in the brain of rats exposed to ischemia. This taurine derivative decreased the mortality rate of animals with ischemic changes in cerebral circulation. The test compound was more potent than piracetam in producing the cerebroprotective effect.

• Authors: N S Sapronov, V V Bul'on, I B Krylova, L K Gavrovskaya, E N Selina, N R Evdokimova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 141 Issue 1 Pg. 44-7 (Jan 2006) ISSN: 0007-4888 [Print] United States
• PMID: 16929961 (Publication Type: Journal Article)

Chemical References

• Neuroprotective Agents
• chlorohydrate-N-isopropylamide-2-(1-phenylethyl)aminoethanesulfonic acid
• Taurine

Topics

• Animals
• Brain Ischemia (drug therapy)
• Energy Metabolism (drug effects)
• Lipid Peroxidation (drug effects)
• Neuroprotective Agents (chemistry, pharmacology, therapeutic use)
• Rats
• Taurine (analogs & derivatives, chemistry, pharmacology, therapeutic use)