Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia.

Abstract

Measurement of tau-protein and beta-amyloid(1-42 )(Abeta42) in cerebrospinal fluid (CSF) has gained increasing acceptance in the differential diagnosis of Alzheimer's disease. We investigated CSF tau-protein and Abeta42 concentrations in 73 patients with advanced idiopathic Parkinson's disease with dementia (PDD) and 23 patients with idiopathic Parkinson's disease without dementia (PD) and in a comparison group of 41 non-demented neurological patients (CG) using commercially available enzyme-linked-immunoabsorbant-assay (ELISA). tau-Protein levels were statistically significantly higher and Abeta42 lower in the PDD patients compared to PD patients and the CG. This observation was most marked (p < 0.05) in a subgroup of patients with PDD carrying the apolipoprotein genotype epsilon3/epsilon3. The distribution of the apolipoprotein genotypes in PDD and PD patients was similar to that of the CG. Although a significant difference in tau-protein values was observed between PDD and CG, no diagnostic cut-off value was established. These findings suggest that such protein CSF changes may help to support the clinical diagnosis of cognitive decline in PD and that there may be apolipoprotein-E-isoform-specific differences in CSF protein regulation in advanced PDD.

• Authors: Brit Mollenhauer, Claudia Trenkwalder, Nicolas von Ahsen, Mirko Bibl, Petra Steinacker, Peter Brechlin, Jan Schindehuette, Sigrid Poser, Jens Wiltfang, Markus Otto
• Journal: Dementia and geriatric cognitive disorders (Dement Geriatr Cogn Disord) Vol. 22 Issue 3 Pg. 200-8 ( 2006) ISSN: 1420-8008 [Print] Switzerland
• PMID: 16899997 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2006 S. Karger AG, Basel

Chemical References

• Amyloid beta-Peptides
• Apolipoproteins E
• Peptide Fragments
• alpha-Synuclein
• amyloid beta-protein (1-42)
• tau Proteins

Topics

• Aged
• Aged, 80 and over
• Alleles
• Amyloid beta-Peptides (cerebrospinal fluid)
• Apolipoproteins E (genetics)
• Dementia (cerebrospinal fluid, etiology, psychology)
• Female
• Gene Frequency
• Genotype
• Humans
• Male
• Middle Aged
• Neuropsychological Tests
• Parkinson Disease (cerebrospinal fluid, complications, psychology)
• Peptide Fragments (cerebrospinal fluid)
• Psychiatric Status Rating Scales
• alpha-Synuclein (cerebrospinal fluid)
• tau Proteins (cerebrospinal fluid)