Abstract | BACKGROUND: OBJECTIVE: To estimate the interactive effects of normal aging and presence of the APOE*4 allele on CSF A beta 42 concentration in adults with normal cognition across the life span. DESIGN: The CSF was collected in the morning after an overnight fast using Sprotte 24-g atraumatic spinal needles. The CSF A beta 42 and A beta 40 concentrations were measured in the 10th milliliter of CSF collected by sandwich enzyme-linked immunosorbent assay. The APOE genotype was determined by a restriction digest method. Subjects One hundred eighty-four community volunteers with normal cognition aged 21 to 88 years. RESULTS: The CSF A beta 42, but not the A beta 40, concentration decreased significantly with age. There was a sharp decrease in CSF A beta 42 concentration beginning in the sixth decade in subjects with the APOE*4 allele. This age-associated decrease in CSF A beta 42 concentration was significantly and substantially greater in subjects with the APOE*4 allele compared with those without the APOE*4 allele. CONCLUSION: These CSF A beta 42 findings are consistent with acceleration by the APOE*4 allele of pathogenic A beta 42 brain deposition starting in later middle age in persons with normal cognition.
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Authors | Elaine R Peskind, Ge Li, Jane Shofer, Joseph F Quinn, Jeffrey A Kaye, Chris M Clark, Martin R Farlow, Charles DeCarli, Murray A Raskind, Gerard D Schellenberg, Virginia M-Y Lee, Douglas R Galasko |
Journal | Archives of neurology
(Arch Neurol)
Vol. 63
Issue 7
Pg. 936-9
(Jul 2006)
ISSN: 0003-9942 [Print] United States |
PMID | 16831961
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Amyloid beta-Peptides
- Apolipoprotein E4
- Apolipoproteins E
- Biomarkers
- Peptide Fragments
- amyloid beta-protein (1-42)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Aging
(cerebrospinal fluid)
- Alleles
- Amyloid beta-Peptides
(cerebrospinal fluid)
- Apolipoprotein E4
- Apolipoproteins E
(genetics)
- Biomarkers
(cerebrospinal fluid)
- Brain
(physiology)
- Cognition
(physiology)
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Peptide Fragments
(cerebrospinal fluid)
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