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Apolipoprotein E4

A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
Also Known As:
Apo E epsilon 4; Apo E-4; Apo E4; ApoE4; Apolipoprotein E-4; Apo E 4; Apolipoprotein E 4
Networked: 2006 relevant articles (54 outcomes, 226 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Huang, Yadong: 42 articles (01/2022 - 12/2002)
2. Michaelson, Daniel M: 31 articles (02/2020 - 02/2003)
3. Bu, Guojun: 26 articles (01/2022 - 10/2006)
4. Sullivan, Patrick M: 26 articles (01/2022 - 06/2002)
5. Weisgraber, Karl H: 22 articles (01/2019 - 10/2002)
6. Mahley, Robert W: 20 articles (01/2019 - 09/2003)
7. Holtzman, David M: 19 articles (02/2022 - 12/2002)
8. Alzheimer’s Disease Neuroimaging Initiative: 19 articles (01/2022 - 01/2015)
9. Alzheimer's Disease Neuroimaging Initiative: 19 articles (10/2021 - 03/2009)
10. LaDu, Mary Jo: 18 articles (10/2022 - 01/2004)

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Dementia (Dementias)
3. Cognitive Dysfunction
4. Inflammation (Inflammations)
5. Infections

Related Drugs and Biologics

1. Apolipoproteins E (ApoE)
2. Apolipoprotein E3
3. Apolipoproteins
4. Apolipoprotein E4
5. Amyloid (Amyloid Fibrils)
6. Lipids
7. Apolipoprotein E2
8. Biomarkers (Surrogate Marker)
9. Cholesterol
10. Triglycerides (Triacylglycerol)

Related Therapies and Procedures

1. Therapeutics
2. Hormone Replacement Therapy (Therapy, Hormone Replacement)
3. Activities of Daily Living (ADL)
4. Drug Therapy (Chemotherapy)
5. Lithotripsy (Extracorporeal Shockwave Lithotripsy)