Abstract | BACKGROUND: Acellular pertussis (aP) booster immunizations have been recommended for adolescents and older persons to enhance long-term protection and to possibly reduce community transmission of infections. METHODS: RESULTS:
Infection rates among control subjects are particularly representative of those in nonimmunized adults. Among control subjects, 0.4%-2.7% had increases in pertussis antibody of various types and degrees over 1 year, and 20%-46% had prolonged cough illnesses during this interval. Pertussis toxin antibody had the greatest specificity for detecting increases in antibody levels. Asymptomatic infections were approximately 5 times more common than clinical illnesses that met a strict clinical and microbiologic case definition. Relative to control subjects, aP-immunized subjects may have fewer increases in the antibody level (i.e., infections), especially for antibodies to fimbriae 2/3 (an antigen not in the vaccine). CONCLUSIONS:
Pertussis infections in older persons are largely asymptomatic. aP boosters confer protection for adolescents and adults against symptomatic pertussis and likely confer protection against mild and asymptomatic infections, and use of boosters may reduce transmission to others, especially infants.
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Authors | Joel I Ward, James D Cherry, Swei-Ju Chang, Susan Partridge, Wendy Keitel, Kathryn Edwards, Martin Lee, John Treanor, David P Greenberg, Stephen Barenkamp, David I Bernstein, Robert Edelman, APERT Study Group |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 43
Issue 2
Pg. 151-7
(Jul 15 2006)
ISSN: 1537-6591 [Electronic] United States |
PMID | 16779740
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Pertussis Vaccine
- Vaccines, Acellular
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Topics |
- Adolescent
- Adult
- Aged
- Bordetella pertussis
- Double-Blind Method
- Humans
- Immunization, Secondary
- Middle Aged
- Pertussis Vaccine
(administration & dosage)
- Prospective Studies
- Vaccination
- Vaccines, Acellular
- Whooping Cough
(prevention & control)
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