Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist.

Abstract	The effects of leuprorelin acetate, a luteinizing hormone-releasing hormone agonist (LHRH-A), on prostate carcinogenesis in probasin/SV40 Tag transgenic rat was investigated. Fifteen weeks after administration of 0.28 and 2.8 mg/kg leuprorelin, prostate weights and serum testosterone levels were significantly decreased compared to values for transgenic controls. Histopathological findings revealed that the incidence of prostatic adenocarcinomas was significantly reduced in ventral, dorsal and lateral lobes of the prostate, correlating with decreased expression of SV40 Tag oncoprotein as well as inhibition of DNA synthesis and proliferation of epithelial cells in neoplastic lesions of the ventral prostate. Microarray analysis further showed leuprorelin acetate to significantly inhibit testicular steroidogenesis, suppressing the expression of SV40 Tag oncoprotein and altering the expression of a large number of genes which might be involved in the inhibition of prostate cancer progression in this rat model.
Authors	Mahmoud M Said, Naomi Hokaiwado, Mingxi Tang, Kumiko Ogawa, Shugo Suzuki, Hala M Ghanem, Amr Y Esmat, Makoto Asamoto, Fawzia M Refaie, Tomoyuki Shirai
Journal	Cancer science (Cancer Sci) Vol. 97 Issue 6 Pg. 459-67 (Jun 2006) ISSN: 1347-9032 [Print] England
PMID	16734723 (Publication Type: Journal Article)
Chemical References	Androgen-Binding Protein Antigens, Polyomavirus Transforming Antineoplastic Agents, Hormonal RNA, Messenger Receptors, Androgen probasin Gonadotropin-Releasing Hormone Testosterone Luteinizing Hormone Follicle Stimulating Hormone Leuprolide
Topics	Adenocarcinoma (drug therapy, genetics) Androgen-Binding Protein (genetics) Animals Animals, Genetically Modified Antigens, Polyomavirus Transforming (genetics) Antineoplastic Agents, Hormonal (pharmacology) Follicle Stimulating Hormone (blood) Gonadotropin-Releasing Hormone (agonists) Immunohistochemistry Leuprolide (pharmacology) Luteinizing Hormone (blood, drug effects) Male Oligonucleotide Array Sequence Analysis Prostate (drug effects) Prostatic Neoplasms (drug therapy, genetics) RNA, Messenger (analysis) Rats Receptors, Androgen (drug effects, metabolism) Reverse Transcriptase Polymerase Chain Reaction Seminal Vesicles (drug effects) Testosterone (blood)

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