[High values of soluble cytokeratin 18 in breast carcinomas may have different meanings].

Abstract

We have investigated the cellular and serum CK18 in 26 non-treated primary ductal invasive breast carcinomas. The soluble CK18 (TPS) was detected by chemiluminescent assay, and the cellular CK18 and PCNA expression by immunocytochemistry. Flow-cytometry was used to estimate the amount of DNA in malignant cells. There was a significant correlation between soluble CK18 and the pre-menopausal status (p < 0.05), characterized in our group by a PCNA estimated low proliferation index. We have also found a significant correlation between soluble CK18 and the DNA index (p < 0.01). The intracellular CK18 has correlated with the PCNA expression (p < 0.05), while no correlation could be found between cellular and serum CK18. The values of soluble CK18 may offer information about the treatment-induced cell death, if monitored, while isolated measurements should be interpreted cautiously. Elevated levels of serum CK18 in non-treated carcinomas may rather reflect a high tumor turn-over or perhaps a more intensive tumor cell killing.

• Authors: P Cianga, Corina Cianga, Ecaterina Anisie, Mihaela Zlei, Didona Ungureanu, Dorina Munteanu, Camelia Chifu, C Diaconu, E Carasevici
• Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi (Rev Med Chir Soc Med Nat Iasi) 2005 Oct-Dec Vol. 109 Issue 4 Pg. 836-40 ISSN: 0048-7848 [Print] Romania
• Vernacular Title: Valorile crescute ale citokeratinei 18 serice in neoplasmele mamare pot avea semnificaţii diferite.
• PMID: 16610185 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers, Tumor
• Peptides
• Proliferating Cell Nuclear Antigen
• tissue polypeptide specific antigen
• Keratins

Topics

• Biomarkers, Tumor (blood)
• Breast Neoplasms (blood, pathology)
• Carcinoma, Ductal, Breast (blood, pathology)
• Female
• Flow Cytometry
• Humans
• Immunohistochemistry
• Keratins (blood)
• Luminescent Measurements
• Peptides (blood)
• Proliferating Cell Nuclear Antigen (blood)