Abstract | BACKGROUND: AIM: PATIENTS AND METHODS: Leukemic samples from 60 children with ALL were tested by the M7T assay for glucocorticoid resistance. Cell cycle before and after ex vivo glucocorticoid treatment was analyzed by flow cytometry. RESULTS: CONCLUSION:
Cortivazol has potent antileukemic activity in childhood ALL. Its activity is related to cell cycle arrest and induction of apoptosis.
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Authors | Jan Styczynski, Andrzej Kurylak, Mariusz Wysocki |
Journal | Anticancer research
(Anticancer Res)
2005 May-Jun
Vol. 25
Issue 3B
Pg. 2253-8
ISSN: 0250-7005 [Print] Greece |
PMID | 16158972
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucocorticoids
- Pregnatrienes
- Prednisolone
- cortivazol
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Topics |
- Adolescent
- Cell Cycle
(drug effects)
- Child
- Child, Preschool
- Drug Resistance, Neoplasm
- Female
- Glucocorticoids
(pharmacology)
- Humans
- Infant
- Lymphocytes
(drug effects, pathology)
- Male
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(drug therapy, pathology)
- Prednisolone
(pharmacology)
- Pregnatrienes
(pharmacology)
- Prognosis
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