Abstract | BACKGROUND: METHODS: In series 1, anesthetized, atelectasis-prone mechanically ventilated rats were randomly assigned to one of six groups based on the inspired oxygen concentration and ventilated without recruitment. Series 2 was performed to determine the cardiac and pulmonary vascular effects of 21% versus 100% inspired oxygen. In series 3, computed tomography scans were performed after ventilation with a recruitment strategy (21% O2) or no recruitment strategy (21% O2 or 100% O2). In series 4, functional residual capacity was measured in animals where the gas was 21% or 100% O2. RESULTS: The partial pressure of arterial oxygen increased with increasing inspired oxygen, but the alveolar-arterial oxygenation gradient was also greater with higher inspired oxygen. Ventilation with 21% O2 (but not with 100% O2) was associated with progressive pulmonary vascular impedance and increased pulmonary vascular permeability. Prostaglandin F2alpha was increased by mechanical ventilation, especially without supplemental oxygen. Computed tomography scans demonstrated no atelectasis in recruited lungs, and atelectasis in nonrecruited lungs that was greater with supplemental oxygen. Increased atelectasis with 100% O2 (vs. 21% O2) was demonstrated by measurement of functional residual capacity. CONCLUSIONS:
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Authors | Michelle Duggan, Patrick J McNamara, Doreen Engelberts, Cecil Pace-Asciak, Paul Babyn, Martin Post, Brian P Kavanagh |
Journal | Anesthesiology
(Anesthesiology)
Vol. 103
Issue 3
Pg. 522-31
(Sep 2005)
ISSN: 0003-3022 [Print] United States |
PMID | 16129977
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Capillary Permeability
- Diastole
(drug effects)
- Dose-Response Relationship, Drug
- Functional Residual Capacity
- Hypertension, Pulmonary
(prevention & control)
- Hypoxia
(complications)
- Lung
(blood supply)
- Male
- Oxygen
(pharmacology)
- Prostaglandins
(physiology)
- Pulmonary Artery
(drug effects)
- Pulmonary Atelectasis
(complications, drug therapy, physiopathology)
- Rats
- Rats, Sprague-Dawley
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