Abstract | BACKGROUND: METHODS: We randomly assigned 420 neonates, born at less than 34 weeks of gestation, with a birth weight of 401 to 1500 g, and with respiratory failure more than four hours after treatment with surfactant to receive placebo (simulated flow) or inhaled nitric oxide (5 to 10 ppm). Infants with a response (an increase in the partial pressure of arterial oxygen of more than 10 mm Hg) were weaned according to protocol. Treatment with study gas was discontinued in infants who did not have a response. RESULTS: CONCLUSIONS:
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Authors | Krisa P Van Meurs, Linda L Wright, Richard A Ehrenkranz, James A Lemons, M Bethany Ball, W Kenneth Poole, Rebecca Perritt, Rosemary D Higgins, William Oh, Mark L Hudak, Abbot R Laptook, Seetha Shankaran, Neil N Finer, Waldemar A Carlo, Kathleen A Kennedy, Jon H Fridriksson, Robin H Steinhorn, Gregory M Sokol, G Ganesh Konduri, Judy L Aschner, Barbara J Stoll, Carl T D'Angio, David K Stevenson, Preemie Inhaled Nitric Oxide Study |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 353
Issue 1
Pg. 13-22
(Jul 07 2005)
ISSN: 1533-4406 [Electronic] United States |
PMID | 16000352
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2005 Massachusetts Medical Society. |
Chemical References |
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Topics |
- Administration, Inhalation
- Bronchopulmonary Dysplasia
(prevention & control)
- Cerebral Hemorrhage
(etiology)
- Combined Modality Therapy
- Female
- Humans
- Infant, Newborn
- Infant, Premature
- Infant, Premature, Diseases
(drug therapy, mortality, therapy)
- Infant, Very Low Birth Weight
- Leukomalacia, Periventricular
(etiology)
- Male
- Nitric Oxide
(adverse effects, therapeutic use)
- Oxygen
(blood)
- Respiration, Artificial
- Respiratory Distress Syndrome, Newborn
(complications)
- Respiratory Insufficiency
(complications, drug therapy, mortality)
- Single-Blind Method
- Treatment Outcome
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