Abstract | BACKGROUND: The present study was designed to determine if estrogens change microtubule polymerization and modulate cell cycle progression in vitro, related to modulation of tubulin expression and to determine if estrogens had antagonistic or synergistic effects with microtubule active agents. METHODS: RESULTS: CONCLUSION: The use of DES and 2-ME enhances the effects of taxanes and may be a novel and important means of increasing therapeutic efficacy of cytotoxic chemotherapy against prostate carcinoma.
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Authors | R Bruce Montgomery, Michael Bonham, Peter S Nelson, Jonathan Grim, Ekram Makary, Robert Vessella, William L Stahl |
Journal | The Prostate
(Prostate)
Vol. 65
Issue 2
Pg. 141-50
(Oct 01 2005)
ISSN: 0270-4137 [Print] United States |
PMID | 15924336
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2005 Wiley-Liss, Inc. |
Chemical References |
- Estrogens
- Taxoids
- Tubulin
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Topics |
- Blotting, Western
- Cell Cycle
(physiology)
- Estrogens
(pharmacology)
- Flow Cytometry
- Humans
- Male
- Oligonucleotide Array Sequence Analysis
- Polymerase Chain Reaction
- Prostatic Neoplasms
(pathology)
- Taxoids
(adverse effects)
- Transcription, Genetic
(drug effects)
- Tubulin
(biosynthesis)
- Tumor Cells, Cultured
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