Abstract | AIM: PATIENTS AND METHODS: We conducted a prospective controlled study of 36 children who had recently been diagnosed with normocholesterolemic minimal change glomerulonephritis with some focal mesangial cell proliferation and moderate proteinuria, and in whom strenuous exercise was restricted. The 36 patients were randomly assigned to receive 20 mg of fluvastatin (group 1) or 5 mg/kg of dipyridamole (group 2) for two years. RESULTS: By the end of the trial, there was no difference in BMD between the groups, and there were no changes in the four bone metabolic parameters. However, the urinary protein, hematuria and BUN levels had significantly decreased in group 1 compared to baseline, and the serum total protein and albumin levels and creatinine clearance had significantly increased in group 1 compared to baseline and group 2. CONCLUSIONS: The results of this study suggest that fluvastatin therapy has an antiproteinuric effect and improves renal function in moderately proteinuric patients with mild histological glomerulonephritis, but does not increase BMD.
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Authors | K Kano, K Nishikura, Y Yamada, O Arisaka |
Journal | Clinical nephrology
(Clin Nephrol)
Vol. 63
Issue 2
Pg. 74-9
(Feb 2005)
ISSN: 0301-0430 [Print] Germany |
PMID | 15730048
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Amino Acids
- Fatty Acids, Monounsaturated
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Indoles
- Isoenzymes
- Osteocalcin
- Fluvastatin
- deoxypyridinoline
- Alkaline Phosphatase
- Acid Phosphatase
- Tartrate-Resistant Acid Phosphatase
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Topics |
- Acid Phosphatase
(blood, drug effects)
- Adolescent
- Adult
- Alkaline Phosphatase
(blood, drug effects)
- Amino Acids
(drug effects, urine)
- Bone Density
(drug effects)
- Child
- Fatty Acids, Monounsaturated
(pharmacology, therapeutic use)
- Female
- Fluvastatin
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(pharmacology, therapeutic use)
- Indoles
(pharmacology, therapeutic use)
- Isoenzymes
(blood, drug effects)
- Male
- Nephritis
(complications, drug therapy, metabolism)
- Nephrosis, Lipoid
(complications, drug therapy, metabolism)
- Osteocalcin
(blood, drug effects)
- Prospective Studies
- Tartrate-Resistant Acid Phosphatase
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