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Dipyridamole (Persantine)

A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Also Known As:
Persantine; Miosen; Antistenocardin; Apo-Dipyridamole; Cerebrovase; Cléridium; Curantil; Curantyl; Dipyramidole; Kurantil; Novo-Dipiradol; Persantin; Apo Dipyridamole; Novo Dipiradol; Ethanol, 2,2',2'',2'''-((4,8-di-1-piperidinylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-
Networked: 3288 relevant articles (230 outcomes, 633 trials/studies)

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Drug Context: Research Results

Experts

1. Picano, Eugenio: 45 articles (12/2021 - 02/2002)
2. Cortigiani, Lauro: 28 articles (12/2021 - 07/2002)
3. Sicari, Rosa: 21 articles (01/2019 - 02/2002)
4. Bovenzi, Francesco: 18 articles (12/2021 - 02/2006)
5. Diener, Hans-Christoph: 17 articles (01/2019 - 09/2001)
6. Rigo, Fausto: 17 articles (01/2019 - 11/2003)
7. Gherardi, Sonia: 14 articles (06/2015 - 08/2005)
8. Bigi, Riccardo: 13 articles (05/2012 - 07/2002)
9. Picano, E: 12 articles (12/2003 - 01/2000)
10. Galderisi, Maurizio: 11 articles (06/2017 - 07/2002)

Related Diseases

1. Stroke (Strokes)
2. Myocardial Infarction
3. Coronary Artery Disease (Coronary Atherosclerosis)
4. Myocardial Ischemia (Ischemic Heart Diseases)
5. Ischemia
03/01/1997 - "Results for sensitivity (89%) and negative predictive value (83%) in group 3 were significantly better than those in group 2 (71% [p = 0.03] and 56% [p = 0.002], respectively) and not significantly different from those in group 1. The polar maps of 20 patients studied with an without dipyridamole at the same exercise level revealed a significantly greater extent of ischemia in each territory and in a global assessment (19 + 20% vs. 8 + 11%, p < 0.0001) when dipyridamole was administered during physical exercise. "
08/01/1989 - "The increase in rate-pressure product (RPP = mm Hg x beats/min x 100) measured during the exercise stress test in the patients in group I was significantly greater than that determined during dipyridamole-induced ischemia (204 +/- 41 versus 145 +/- 33, p less than 0.01). "
06/01/1983 - "Rapid atrial pacing performed before and at 60, 90, and 120 minutes after dipyridamole failed to demonstrate any significant reduction in pacing threshold or evidence of increased ischemia after dipyridamole. "
11/10/2023 - "Our study suggests that reversible ischemia by wall motion assessment and CFVR-LAD on dipyridamole SE are independently associated with dismal outcome in patients with suspected or known stable CAD, even after accounting for angiographic anatomic CAD severity and also independently from which coronary artery is diseased."
06/01/2010 - "The aim of this study was to compare the feasibility and diagnostic accuracy of high-volume rate 3DE with state-of-the-art two-dimensional echocardiography (2DE) in detecting ischemia during dipyridamole-induced stress (DipSE). "

Related Drugs and Biologics

1. Aspirin (Acetylsalicylic Acid)
2. Clopidogrel (Plavix)
3. Platelet Aggregation Inhibitors (Antiplatelet Drugs)
4. Adenosine (Adenocard)
5. Thallium
6. Ticlopidine (Ticlid)
7. Prednisolone (Predate)
8. Thallium-201
9. Warfarin (Coumadin)
10. Dobutamine

Related Therapies and Procedures

1. Therapeutics
2. Secondary Prevention
3. Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4. Renal Dialysis (Hemodialysis)
5. Prostheses and Implants (Prosthesis)