Both
irritable bowel syndrome and
inflammatory bowel diseases share symptoms of altered bowel habits associated with
abdominal pain or discomfort.
Irritable bowel syndrome has been referred to as a functional bowel disorder, which is diagnosed by a characteristic cluster of symptoms in the absence of detectable structural abnormalities.
Inflammatory bowel disease is a heterogeneous group of disorders characterized by various forms of chronic mucosal and/or transmural
inflammation of the intestine. In this review, the authors discuss recent evidence suggesting several potential mechanisms that might play a pathophysiologic role in both syndromes. Possible shared pathophysiologic mechanisms include altered mucosal permeability, an altered interaction of
luminal flora with the mucosal immune system, persistent mucosal immune activation, alterations in gut motility, and a role of severe, sustained life stressors in symptom modulation. It is proposed that similarities and differences between the two syndromes can best be addressed within the framework of interactions between the central nervous system and the gut immune system. Based on recent reports of low-grade mucosal
inflammation in subpopulations of patients meeting current diagnostic criteria for
irritable bowel syndrome, therapeutic approaches shown to be effective in
inflammatory bowel disease, such as probiotics,
antibiotics, and
antiinflammatory agents, have been suggested as possible
therapies for certain patients with
irritable bowel syndrome.