Abstract | AIM: METHODS: We retrospectively reviewed clinical, biochemical and image data of 1,154 HCC patients. In addition, we measured platelet count and serum TPO in HCC patients with and without thrombocytosis, in patients with cirrhosis, chronic hepatitis and healthy subjects in a cross-sectional study. RESULTS: Thirty-one (2.7%) of 1,154 HCC patients had thrombocytosis (platelet count > or = 400 K/mm3). HCC patients with thrombocytosis were significantly younger, had a higher serum alpha-fetoprotein, higher rate of main portal vein thrombosis, larger tumor volume, shorter survival, and were less likely to receive therapy than HCC patients without thrombocytosis. Multivariate logistic regression analyses showed that tumor volumes > or = 30% and serum alpha-fetoprotein > or = 140,000 ng/mL could significantly predict thrombocytosis. HCC patients with thrombocytosis had a significantly higher mean serum TPO than those without, as well as patients with cirrhosis, chronic hepatitis and healthy subjects. Platelet count and serum TPO dropped significantly after tumor resection in HCC patients with thrombocytosis and re-elevated after tumor recurred. Furthermore, the expression of TPO mRNA was found to be more in tumor tissues than in non- tumor tissues of liver in an HCC patient with thrombocytosis. CONCLUSION:
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Authors | Shinn-Jang Hwang, Jiing-Chyuan Luo, Chung-Pin Li, Cheng-Wei Chu, Jaw-Ching Wu, Chiung-Ru Lai, Jen-Huei Chiang, Gar-Yang Chau, Wing-Yiu Lui, Chun-Chung Lee, Full-Young Chang, Shou-Dong Lee |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 10
Issue 17
Pg. 2472-7
(Sep 01 2004)
ISSN: 1007-9327 [Print] United States |
PMID | 15300887
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2004 The WJG Press ISSN |
Chemical References |
- alpha-Fetoproteins
- Thrombopoietin
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Hepatocellular
(blood, complications)
- Cross-Sectional Studies
- Female
- Humans
- Liver Cirrhosis
(blood, complications)
- Liver Neoplasms
(blood, complications)
- Male
- Middle Aged
- Paraneoplastic Syndromes
(blood, complications)
- Platelet Count
- Retrospective Studies
- Thrombocytosis
(blood, etiology)
- Thrombopoietin
(blood)
- alpha-Fetoproteins
(metabolism)
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