Hepatoblastoma

A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)

Also Known As:

Networked: 2081 relevant articles (102 outcomes, 316 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Neoplasm Metastasis (Metastasis)
3.	Wilms Tumor (Wilm's Tumor)
4.	Rhabdomyosarcoma
5.	Ewing Sarcoma (Sarcoma, Ewing)

Experts

1.	Ranganathan, Sarangarajan: 22 articles (10/2022 - 07/2005)
2.	von Schweinitz, Dietrich: 22 articles (01/2021 - 10/2003)
3.	Hiyama, Eiso: 20 articles (01/2022 - 06/2002)
4.	Fuchs, Jörg: 20 articles (11/2021 - 07/2002)
5.	Warmann, Steven W: 20 articles (11/2021 - 04/2005)
6.	Finegold, Milton J: 17 articles (10/2022 - 02/2002)
7.	Czauderna, Piotr: 16 articles (01/2020 - 05/2005)
8.	Perilongo, Giorgio: 16 articles (01/2020 - 02/2003)
9.	Hishiki, Tomoro: 15 articles (03/2022 - 01/2011)
10.	Katzenstein, Howard M: 15 articles (01/2022 - 08/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hepatoblastoma:

1.	Cisplatin (Platino)FDA LinkGeneric 05/01/2022 - "Recent SIOPEL studies have shown cisplatin monotherapy to be equally effective in management of Standard risk Hepatoblastoma (SRHB)as compared to PLADO. " 04/27/2018 - "An in vivo model of human hepatoblastoma was utilized to study the effects of PIM inhibition alone and in combination with cisplatin. " 01/01/2018 - "In this study, we investigate the use of cisplatin dose adaptation based on therapeutic drug monitoring in a 2-week-old neonate with localized hepatoblastoma. " 01/01/2018 - "The aim of the present study was to determine the antitumor activity and mechanism of ginkgol C17:1 in combination with cisplatin in human hepatoblastoma HepG2 cells. " 06/20/2006 - "Results from this and other therapeutic trials suggested that cisplatin was the most active agent against hepatoblastoma. "
2.	Doxorubicin (Adriamycin)FDA LinkGeneric 08/01/1980 - "Adriamycin alone, or in combination with other agents, has proven effective in primary and metastatic childhood hepatoblastoma. " 03/01/2017 - "In this study, we assessed the role of GATA4 in doxorubicin-induced apoptosis of hepatoblastoma cells. " 01/01/2019 - "Finally, LRA treatment enhanced the cytotoxic effects of doxorubicin on hepatoblastoma cells. " 03/01/2017 - "Herein, we demonstrate that doxorubicin decreases GATA4 expression and alters the expression pattern of BCL2 family members, most profoundly that of BCL2 and BAK, in the HUH6 hepatoblastoma cell line. " 03/01/2017 - "An essential drug in the treatment of hepatoblastoma is doxorubicin, which in high doses is cardiotoxic. "
3.	Irinotecan (Camptosar)FDA LinkGeneric 10/01/2020 - "Sustained Remission After Maintenance Irinotecan in Patient With Multiply Relapsed Hepatoblastoma." 07/01/2013 - "[Preliminary study on the efficacy of irinotecan in the treatment of childhood relapsed hepatoblastoma]." 12/01/2012 - "Efficacy of irinotecan single drug treatment in children with refractory or recurrent hepatoblastoma--a phase II trial of the childhood liver tumour strategy group (SIOPEL)." 10/01/2020 - "Irinotecan as maintenance should be explored in recurrent hepatoblastoma." 12/01/2012 - "Exploration of the role of irinotecan in the initial treatment of hepatoblastoma is warranted."
4.	Vincristine (Oncovin)FDA LinkGeneric 05/01/2015 - "Formal prospective investigation of the relative risks and benefits of vincristine in hepatoblastoma treatment is warranted to assess the value of continued use of vincristine in this patient population. " 05/01/2015 - "We evaluated the incidence of vincristine-related sensorimotor peripheral, autonomic, and cranial nerve neurological morbidities in 45 consecutive hepatoblastoma patients treated at our institution. " 05/01/2015 - "Further examination of the risk and benefit profile of vincristine relevant to hepatoblastoma clinical care paradigms is thus warranted. " 05/01/2015 - "Vincristine-associated neurological morbidity in the treatment of hepatoblastoma." 08/15/2012 - "A two-year-old African-American girl with stage IV hepatoblastoma arrived at a clinic to receive her fourth dose of vincristine as part of standard induction therapy. "
5.	AnthracyclinesIBA 06/20/2018 - "A detailed echocardiographic examination was performed in 36 children with hepatoblastoma or rhabdomyosarcoma after receiving anthracyclines' chemotherapy and 36 healthy controls from January 2015 to December 2016. " 09/04/2014 - "For Wilms' tumour, rhabdomyosarcoma and undifferentiated sarcoma, Ewing's sarcoma, non-Hodgkin lymphoma, hepatoblastoma and AML only one RCT was available for each type and, therefore, no definitive conclusions can be made about the antitumour efficacy of treatment with or without anthracyclines in these tumours. " 01/19/2011 - "For Wilms' tumour, rhabdomyosarcoma/undifferentiated sarcoma, Ewing's sarcoma, non-Hodgkin lymphoma and hepatoblastoma only one RCT was available and, therefore, no definitive conclusions can be made about the antitumour efficacy of treatment with or without anthracyclines in these tumours. " 07/23/2021 - "Anthracyclines are highly effective against most types of childhood cancer, such as neuroblastoma, hepatoblastoma, nephroblastoma, rhabdomyosarcoma, Ewing sarcoma, and so forth. " 09/01/1984 - "For hepatoblastomas, chemotherapy should consist of vincristine, cyclophosphamid, adriamycin and actinomycin-D whereas the hepatocellular carcinoma responds best to anthracyclines. "
6.	Proteins (Proteins, Gene)FDA Link 12/01/2015 - "The aim of this study was to ascertain whether Trx and/or Grx systems mediate the antiproliferative effect of NO on hepatoblastoma cells by modulating the redox-state of key proteins. " 02/01/2015 - "The aim of the present study was to improve the purification method of rHespintor, increase the protein extraction efficiency, and investigate its effects on the proliferation, migration and invasion of the HepG2 hepatoblastoma cell line. " 07/01/2014 - "In this study, Hespintor, a protein with unknown function, was screened and obtained from the hepatoblastoma cell line, HepG2, using suppression subtractive hybridization (SSH). " 09/01/2009 - "In this study, the human hepatoblastoma HepG2 cell line harboring 1.2 x unit-length of the HBV genome was generated and subjected to a proteomic approach analyzing the global protein expression profiles of HepG2 cells with and without HBV replication and protein expression. " 04/01/2008 - "We have investigated in the present study if this protein is expressed in human hepatoblastomas. "
7.	PlatinumIBA 06/20/2006 - "Intensification of therapy by alternating platinum analogs increased the risk of adverse outcome in children with unresectable or metastatic hepatoblastoma." 06/20/2006 - "Intensified platinum therapy is an ineffective strategy for improving outcome in pediatric patients with advanced hepatoblastoma." 12/15/2009 - "The current study was conducted to determine whether amifostine is effective in reducing the toxicities associated with the administration of platinum-containing regimens in children with hepatoblastoma (HB). " 08/01/2002 - "By contrast, Bamet-D3 [(N'N'' cis-dichloro N(3-3-amminepropylammine)propyl) glycocholamide platinum (II)] was only effective in reducing growth in human hepatoblastoma HepG2 cells. " 03/01/2022 - "Hepatoblastoma (HB) is a common primary malignant liver tumour in children, mainly treated by means of traditional chemotherapy using platinum and doxorubicin (ADM). "
8.	Sorafenib (BAY 43-9006)FDA Link 09/01/2021 - "C/EBPβ enhances efficacy of sorafenib in hepatoblastoma." 07/01/2023 - "Corrigendum to 'Regulation of cell death receptor S-nitrosylation and apoptotic signaling by Sorafenib in hepatoblastoma cells'[Redox Biol 6(2015):174-182]." 12/01/2015 - "In conclusion, Sorafenib induced alteration of cell death receptor S-nitrosylation status which may have a relevant repercussion on cell death signaling in hepatoblastoma cells." 12/01/2015 - "Regulation of cell death receptor S-nitrosylation and apoptotic signaling by Sorafenib in hepatoblastoma cells." 02/05/2013 - "Sorafenib has recently been shown to reduce tumour growth in hepatoblastoma (HB) xenografts. "
9.	Topotecan (Hycamtin)FDA LinkGeneric 11/01/2001 - "Successful therapy of subcutaneously growing human hepatoblastoma xenografts with topotecan." 06/01/2008 - "The expression of Bcl-XL, Bcl-XS and p27Kip1 in topotecan-induced apoptosis in hepatoblastoma HepG2 cell line." 06/01/2002 - "Metronome topotecan inhibits growth and neovascularization in experimental hepatoblastoma. " 06/01/2002 - "The authors developed a xenograft model of human hepatoblastoma to test the effect of metronome topotecan in this system. " 06/01/2002 - "Topotecan is anti-angiogenic in experimental hepatoblastoma."
10.	DNA (Deoxyribonucleic Acid)IBA 05/01/2020 - "Previous studies showed a correlation between DNA hypermethylation and hepatoblastoma progression. " 12/01/2001 - "This study was done to explore the evidence that liver cells were oxidatively damaged, based on the hypothesis that oxidative damage to DNA is involved in the development of hepatoblastoma in children of low birth weight. " 01/01/2022 - "A novel risk stratification model based on the Children's Hepatic Tumours International Collaboration-Hepatoblastoma Stratification and deoxyribonucleic acid methylation analysis for hepatoblastoma." 01/01/2019 - "Our findings support a model of active demethylation by TETs in hepatoblastoma, probably during early stages of liver development, which in combination with UHRF1 overexpression would lead to DNA hypomethylation and an increase in overall 5hmC content. " 11/01/2013 - "The biocompatibility of the synthesized LFMCSMs was evaluated in vitro by assessing their cytotoxic and genotoxic effect on human hepatoblastoma (HepG2) cells using MTT, TUNEL, fluorescent staining, DNA ladder and Gene expression assays respectively. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 03/01/1999 - "Though most patients with nonmetastatic hepatoblastomas can be cured by defining surgical strategies and chemotherapy regimes, new drugs are needed for children with advanced hepatoblastomas. " 07/01/1997 - "This protocol of preoperative chemotherapy appears to be safe and effective for most children who have hepatoblastoma." 01/01/2011 - "In the recent years, surgical resection with pre- and/or postoperative chemotherapy has markedly improved the survival rate of hepatoblastoma patients. " 05/20/2010 - "The primary objective was to determine the efficacy of a newly designed preoperative chemotherapy regimen in an attempt to improve the cure rate of children with high-risk hepatoblastoma. " 02/01/1990 - "A rare case of hepatoblastoma originating in the caudate lobe was treated successfully with intraarterial chemotherapy followed by extensive lobectomy of the left side of the liver. "
2.	Liver Transplantation 08/12/2021 - "Liver Transplantation Is Highly Effective in Children with Irresectable Hepatoblastoma." 06/01/2017 - "Dramatic advancement has been made in the management of children with hepatoblastoma (HB) over the past 3 decades owing to the improvement in diagnostic imaging, new chemotherapeutic agents, better surgical care and availability of liver transplantation. " 09/15/2002 - "Liver transplantation is an effective treatment for unresectable unifocal or multifocal hepatoblastoma confined to the liver. " 10/02/2019 - "The incidence of hepatoblastoma is increasing, and liver transplant (LT) provides a potential cure for pediatric patients with unresectable hepatoblastoma; however, the use of LT for hepatoblastoma has not been examined in a modern cohort. " 01/01/2022 - "Further studies are warranted to better understand the role of salvage liver transplant in the treatment of hepatoblastoma. "
3.	Therapeutics 05/01/2003 - "In these cases HD-therapy with these drugs is highly efficient and enables a remission in the majority of advanced and metastasised HR-hepatoblastoma. " 01/01/2020 - "Treatment outcomes for hepatoblastoma have improved markedly in the contemporary treatment era, principally due to therapy intensification, with overall survival increasing from 35% in the 1970s to 90% at present. " 08/15/2014 - "We believe this model may offer a valuable new tool to improve understanding of the cellular etiology and biology of HCC and hepatoblastomas and the development of improved therapeutics for these diseases." 12/01/2010 - "In Hepatoblastoma (HB) apoptosis regulation contributes to resistance and therapy failure, therefore we modulated apoptosis sensitivity of HB cells for an improved cytotoxic activity of commonly used drugs. " 06/01/2002 - "Cytotoxic targeting of endothelial cells may hold particular promise for therapy of children with advanced hepatoblastoma. "
4.	Neoadjuvant Therapy 01/01/2016 - "In this article, we present 2 cases of hepatoblastoma treated 15 years ago by neoadjuvant chemotherapy and surgery, and are presenting for long term follow-up with complete disease remission. " 11/20/2023 - "Computed tomography imaging phenotypes of hepatoblastoma identified from radiomics signatures are associated with the efficacy of neoadjuvant chemotherapy." 08/07/2014 - "Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas: 10 year single-center experience and literature review." 05/01/2014 - "The use of neoadjuvant chemotherapy has improved the survival of patients with hepatoblastoma (HB). " 01/01/2023 - "The objective of this study is to assess the prognostic value of the preoperative inflammatory indexes in pediatric hepatoblastoma patients who receive neoadjuvant chemotherapy. "
5.	Hepatectomy 03/14/2011 - "To evaluate the efficacy of the two-surgeon technique with the liver hanging maneuver (LHM) for hepatectomies in pediatric patients with hepatoblastoma. " 01/01/2023 - "The patient underwent a left hepatectomy, and hepatoblastoma was discovered by histology of the resected hepatic lobe. " 01/01/2021 - "Segment 6 monosegment-preserving hepatectomy for hepatoblastoma: individualizing treatment beyond the resectability criteria." 04/01/2020 - "Impact of microscopically margin-positive resection on survival in children with hepatoblastoma after hepatectomy: a retrospective cohort study." 01/01/2020 - "Laparoscopic-assisted extended right hepatectomy for hepatoblastoma in a child (Video)."