Abstract |
To improve the antimyeloma effect of donor lymphocyte infusion (DLI) after allogeneic stem cell transplantation in multiple myeloma, we investigated in a phase 1/2 study the effect of low-dose thalidomide (100 mg) followed by DLI in 18 patients with progressive disease or residual disease and prior ineffective DLI after allografting. The overall response rate was 67%, including 22% complete remission. Major toxicity of thalidomide was weakness grade I/II (68%) and peripheral neuropathy grade I/II (28%). Only 2 patients experienced mild grade I acute graft versus host disease (aGvHD) of the skin, while no grades II to IV aGvHD was seen. De novo limited chronic GvHD (cGvHD) was seen in 2 patients (11%). The 2-year estimated overall and progression-free survival were 100% and 84%, respectively. Adoptive immunotherapy with low-dose thalidomide and DLI induces a strong antimyeloma effect with low incidence of graft versus host disease.
|
Authors | Nicolaus Kröger, Avichai Shimoni, Maria Zagrivnaja, Francis Ayuk, Michael Lioznov, Heike Schieder, Helmut Renges, Boris Fehse, Tatjana Zabelina, Arnon Nagler, Axel R Zander |
Journal | Blood
(Blood)
Vol. 104
Issue 10
Pg. 3361-3
(Nov 15 2004)
ISSN: 0006-4971 [Print] United States |
PMID | 15292062
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Immunosuppressive Agents
- Thalidomide
|
Topics |
- Adult
- Combined Modality Therapy
- Graft vs Host Disease
(epidemiology)
- Hematopoietic Stem Cell Transplantation
- Humans
- Immunosuppressive Agents
(administration & dosage, adverse effects)
- Immunotherapy, Adoptive
- Incidence
- Middle Aged
- Multiple Myeloma
(drug therapy)
- Remission Induction
- Thalidomide
(administration & dosage, adverse effects)
- Transplantation, Homologous
- Treatment Outcome
|