Abstract | AIMS/HYPOTHESIS: METHODS: RESULTS: Supplementation with t10c12CLA increased proinsulin (p<0.01), the proinsulin : insulin ratio (p<0.05) and C-peptide concentrations (p<0.001) in comparison with control subjects. Adiponectin, however, did not change significantly. The change in proinsulin, but not the proinsulin : insulin ratio, was related to impaired insulin sensitivity (r= -0.58, p<0.0001), independently of changes in insulin, C-peptide, glucose, adiponectin and BMI. Conversely, the correlation between insulin sensitivity and specific insulin (r=-0.46, p<0.001) did not remain significant after adjustment for proinsulin. Induced hyperproinsulinaemia was also correlated to adiponectin concentrations ( r= -0.34, p<0.01). CONCLUSIONS/INTERPRETATION:
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Authors | U Risérus, B Vessby, P Arner, B Zethelius |
Journal | Diabetologia
(Diabetologia)
Vol. 47
Issue 6
Pg. 1016-9
(Jun 2004)
ISSN: 0012-186X [Print] Germany |
PMID | 15168020
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Blood Glucose
- C-Peptide
- Intercellular Signaling Peptides and Proteins
- Linoleic Acids, Conjugated
- trans-10,cis-12-conjugated linoleic acid
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Topics |
- Abdomen
(anatomy & histology, physiopathology)
- Adiponectin
- Adipose Tissue
(anatomy & histology, physiopathology)
- Analysis of Variance
- Blood Glucose
(analysis)
- C-Peptide
(blood)
- Dietary Supplements
- Double-Blind Method
- Drug Administration Schedule
- Humans
- Hyperinsulinism
(blood, chemically induced, complications)
- Insulin Resistance
- Intercellular Signaling Peptides and Proteins
(blood)
- Linoleic Acids, Conjugated
(administration & dosage, adverse effects, metabolism)
- Male
- Obesity
(complications, physiopathology)
- Time Factors
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