Abstract | BACKGROUND: METHODS: We evaluated 151 children aged 12 years or younger who had uncomplicated P. falciparum malaria. Patients were randomly assigned pyrimethamine-sulphadoxine (25 mg/kg of the sulphadoxine component) or pyrimethamine-sulphadoxine as above plus probenecid 20-25 mg/kg of bodyweight in two divided doses daily for 3 days. The primary endpoints were parasitological cure rates on days 14 and 28. RESULTS: Both regimens were well tolerated; no child was withdrawn because of drug intolerance. Fever (1.9 +/- 1.1 vs. 2.4 +/- 1.2 days, P = 0.02) and parasite clearance (2.3 +/- 0.9 vs. 2.7 +/- 1.1 days, P = 0.04) were significantly shorter, and the parasitological cure rate on day 14 (96.2%vs. 83.5%, P = 0.02) but not day 28 (79.4%vs. 72.6%, P = 0.4), was significantly higher in children treated with pyrimethamine-sulphadoxine- probenecid than in those treated with pyrimethamine-sulphadoxine. Gametocyte carriage was similar with both treatment regimens. CONCLUSIONS: The combination of pyrimethamine-sulphadoxine, and probenecid, at a relatively moderate dose, improved treatment efficacy but had no effect on gametocyte carriage. The pyrimethamine-sulphadoxine- probenecid combination merits further evaluation as a potential treatment for use in Nigeria.
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Authors | A Sowunmi, F A Fehintola, A A Adedeji, G O Gbotosho, C O Falade, E Tambo, B A Fateye, T C Happi, A M J Oduola |
Journal | Tropical medicine & international health : TM & IH
(Trop Med Int Health)
Vol. 9
Issue 5
Pg. 606-14
(May 2004)
ISSN: 1360-2276 [Print] England |
PMID | 15117306
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimalarials
- Drug Combinations
- Multidrug Resistance-Associated Proteins
- Organic Anion Transporters
- fanasil, pyrimethamine drug combination
- Sulfadoxine
- Probenecid
- Pyrimethamine
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Topics |
- Acute Disease
- Antimalarials
(administration & dosage, adverse effects)
- Child
- Child, Preschool
- Drug Combinations
- Drug Interactions
- Drug Resistance, Multiple
(drug effects)
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Humans
- Infant
- Malaria, Falciparum
(drug therapy)
- Male
- Multidrug Resistance-Associated Proteins
(antagonists & inhibitors)
- Organic Anion Transporters
(antagonists & inhibitors)
- Parasitemia
(drug therapy)
- Probenecid
(administration & dosage, adverse effects)
- Pyrimethamine
(administration & dosage, adverse effects)
- Sulfadoxine
(administration & dosage, adverse effects)
- Treatment Outcome
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