Organic Anion Transporters

Proteins involved in the transport of organic anions. They play an important role in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body.
Also Known As:
OAT Transport Proteins; OATP Proteins; OATP Transporters; Organic Anion Transport Proteins; Anion Transporters, Organic; Transport Proteins, OAT; Transporters, OATP; Transporters, Organic Anion; Membrane Transport Proteins, Organic Anion; Organic Anion Transport Polypeptides
Networked: 63 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. You, Guofeng: 7 articles (01/2012 - 07/2004)
2. Gartung, Carsten: 6 articles (11/2005 - 06/2002)
3. Geier, Andreas: 6 articles (11/2005 - 06/2002)
4. Dietrich, Christoph G: 6 articles (11/2005 - 06/2002)
5. Matern, Siegfried: 6 articles (11/2005 - 06/2002)
6. Stieger, Bruno: 5 articles (04/2014 - 08/2002)
7. Brandoni, Anabel: 4 articles (11/2012 - 05/2006)
8. Torres, Adriana M: 4 articles (01/2010 - 05/2006)
9. Zhou, Fanfan: 4 articles (07/2007 - 07/2004)
10. Lammert, Frank: 4 articles (11/2005 - 06/2002)

Related Diseases

1. Infection
2. Breast Neoplasms (Breast Cancer)
06/01/2007 - "Additional studies have shown that efflux transporters, such as multi-drug resistance-associated protein 2, breast cancer-resistant protein and the organic anion transporters, appear to serve as the gate keeper when there is an excess capacity to metabolise the compounds. "
03/01/2014 - "These transporters include members belonging to the organic cation/anion/zwitterion solute carrier family, such as the organic anion transporters (OAT)1, OAT3, and OATP4C1, and to the adenosine triphosphate binding cassette superfamily of transmembrane transporters, including the multidrug resistance proteins and breast cancer resistance protein. "
01/01/2012 - "Protein and mRNA expression of influx transporters [organic anion-transporting polypeptide (Oatp), organic anion transporter (Oat)] and efflux transporters [P-glycoprotein (P-gp), multidrug resistance-related protein (Mrp), breast cancer resistance protein (Bcrp)] were measured in CRF and control rat brain. "
02/01/2008 - "Other transporters such as the influx transporters organic anion transporting polypeptide (OATP)-B, OATP-C, and OATP8 and the efflux pumps multidrug resistance-associated protein (MRP) 2, MRP3, MRP4, and breast cancer resistance protein were also down-regulated at mRNA levels in human hepatocytes treated by IL-1beta for 24 h, and most of these transporters were similarly repressed in IL-1beta-exposed HepaRG cells; the cytokine also reduced bile salt export pump (BSEP) and OATP-C protein expression in human hepatocytes. "
11/01/2006 - "Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats."
3. Cholestasis
4. Ischemia
5. Hepatocellular Carcinoma (Hepatoma)

Related Drugs and Biologics

1. Probenecid (Benemid)
2. P-Glycoprotein
3. Peptides
4. P-Glycoproteins
5. Anions
6. p-Aminohippuric Acid (p-Aminohippurate)
7. Hypoglycemic Agents (Hypoglycemics)
8. lenalidomide (CC 5013)
9. Antihypertensive Agents (Antihypertensives)
10. Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1. Hepatectomy
2. Therapeutics
3. Drug Therapy (Chemotherapy)