Abstract | BACKGROUND/AIMS: The purpose of this study was to extend previous publications and examine the Vaccine Adverse Events Reporting System (VAERS) database for the incidence of gastrointestinal reactions reported following tetra-valent rhesus-human reassortant rotavirus vaccine ( RRV-TV). METHODOLOGY: RESULTS: The results of a chi-square analysis showed that rotavirus vaccine was statistically significantly over represented by serious gastrointestinal reactions in comparison to vaccine control groups. CONCLUSIONS: This analysis demonstrated that the VAERS database provides a way to detect whether RRV-TV elevates the risk of adverse reactions compared to control vaccines given to similar age groups when appropriate denominators (number of annual doses given) are employed. Because of its massive size and the availability of numerous vaccine control groups, the VAERS database provides data on adverse reactions following vaccination that is available nowhere else.
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Authors | David A Geier, Mark R Geier |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2004 Mar-Apr
Vol. 51
Issue 56
Pg. 465-9
ISSN: 0172-6390 [Print] Greece |
PMID | 15086184
(Publication Type: Journal Article)
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Chemical References |
- Hepatitis B Vaccines
- Poliovirus Vaccine, Oral
- Rotavirus Vaccines
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Topics |
- Adverse Drug Reaction Reporting Systems
- Chi-Square Distribution
- Databases, Factual
- Gastrointestinal Diseases
(etiology)
- Hepatitis B Vaccines
(adverse effects)
- Humans
- Poliovirus Vaccine, Oral
(adverse effects)
- Retrospective Studies
- Rotavirus Vaccines
(adverse effects)
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