Abstract | INTRODUCTION: MATERIAL AND METHODS: RESULTS: Histopathologically, inflammatory cells infiltrated the endocardium and all seven patients showed features of persistent myocarditis. Activated T cells [15.3+/-9.4 cells/high power field (HPF, mean+/-S.D.) vs. control 2.2+/-4.4/HPF (P=0.0294)] and a few macrophages [5.1+/-8.4 cells/HPF vs. control 2.4+/-3.5 cells/HPF (P=NS)] infiltrated the endocardium. Tissue factor was overexpressed in the endothelia particularly in tissues containing inflammatory cells and denuded matrix of the endocardium, compared with the control group. Von Willebrand factor, but not tissue factor pathway inhibitor, was also overexpressed in these tissues. CONCLUSION:
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Authors | Yoichi Nakamura, Kazufumi Nakamura, Kengo Fukushima-Kusano, Keiko Ohta, Hiromi Matsubara, Tsutomu Hamuro, Chikao Yutani, Tohru Ohe |
Journal | Thrombosis research
(Thromb Res)
Vol. 111
Issue 3
Pg. 137-42
( 2003)
ISSN: 0049-3848 [Print] United States |
PMID | 14678810
(Publication Type: Journal Article)
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Chemical References |
- von Willebrand Factor
- Thromboplastin
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Topics |
- Aged
- Atrial Fibrillation
(pathology)
- Endocardium
(pathology)
- Endothelium, Vascular
(metabolism)
- Female
- Heart Atria
(metabolism)
- Humans
- Immunohistochemistry
- Inflammation
- Male
- Middle Aged
- Myocarditis
(metabolism, pathology)
- Thromboplastin
(biosynthesis)
- von Willebrand Factor
(metabolism)
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