Abstract | OBJECTIVE: STUDY DESIGN: Patients with KD (n=32) were randomized to receive either i.v.GG alone (G group) or i.v.GG plus corticosteroids (G+S group). The clinical course and cytokine responses between groups were compared. RESULTS: The pretreatment serum levels of interleukin (IL)-2, IL-6, IL-8, and IL-10 were significantly higher in patients with KD than in healthy controls. Although i.v.GG alone failed to reduce cytokine concentrations within 24 hours of i.v.GG administration, corticosteroids plus i.v.GG reduced IL-2, IL-6, IL-8, and IL-10 levels. The levels of IL-2, IL-6, IL-8, and IL-10 within 24 hours after initiating i.v.GG therapy were significantly lower in the G+S group than in the G group. The duration of fever was shorter, and the C-reactive protein concentration decreased more quickly in the G+S group than in the G group. CONCLUSIONS: These findings suggest that corticosteroids rapidly ameliorate symptoms by reducing cytokine levels in children with KD.
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Authors | Yasunori Okada, Makoto Shinohara, Tomio Kobayashi, Yoshinari Inoue, Takeshi Tomomasa, Tohru Kobayashi, Akihiro Morikawa, Gunma Kawasaki Disease Study Group |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 143
Issue 3
Pg. 363-7
(Sep 2003)
ISSN: 0022-3476 [Print] United States |
PMID | 14517521
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents
- Cytokines
- gamma-Globulins
- Prednisolone
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Topics |
- Acute-Phase Reaction
(blood, drug therapy, etiology)
- Anti-Inflammatory Agents
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Cytokines
(blood, drug effects)
- Drug Therapy, Combination
- Female
- Humans
- Infant
- Infusions, Intravenous
- Male
- Mucocutaneous Lymph Node Syndrome
(blood, complications, drug therapy)
- Outcome Assessment, Health Care
- Prednisolone
(administration & dosage, therapeutic use)
- Prospective Studies
- Severity of Illness Index
- Time Factors
- gamma-Globulins
(administration & dosage, therapeutic use)
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