Risperidone-induced obsessive-compulsive symptoms in two children.

Abstract

OBJECTIVE:

To present two cases of rapid-onset obsessive-compulsive symptoms in children treated with risperidone.

CASES:

"A" was an 8-year-old boy with attention deficit and chronic tic disorder who developed obsessive-compulsive symptoms within 2 weeks of starting risperidone. When the dose of 0.5 mg tid was discontinued, the obsessive-compulsive symptoms resolved with no return over 8 months of follow-up. "B" was an 11-year-old girl with mild mental retardation and aggression who was treated with risperidone 1 mg per day. Obsessive-compulsive symptoms suddenly emerged 10 days after starting risperidone and resolved within 3 days of discontinuation. In both cases, streptococcal pharyngitis was ruled out.

CONCLUSION:

Although the mechanism is not clear, these cases add to several other reports concerning the sudden emergence of obsessive-compulsive symptoms and anxiety symptoms in children treated with atypical antipsychotics. Clinicians should be alert to the possibility of these adverse effects in children treated with these drugs.

• Authors: Rasim Somer Diler, Aysegul Yolga, Ayse Avci, Lawrence Scahill
• Journal: Journal of child and adolescent psychopharmacology (J Child Adolesc Psychopharmacol) Vol. 13 Suppl 1 Pg. S89-92 ( 2003) ISSN: 1044-5463 [Print] United States
• PMID: 12880504 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antipsychotic Agents
• Risperidone

Topics

• Adult
• Aggression
• Antipsychotic Agents (adverse effects, therapeutic use)
• Attention Deficit Disorder with Hyperactivity (complications, drug therapy, psychology)
• Female
• Humans
• Intellectual Disability (complications, psychology)
• Male
• Obsessive-Compulsive Disorder (chemically induced, psychology)
• Risperidone (adverse effects, therapeutic use)
• Tic Disorders (complications, drug therapy, psychology)