Tic Disorders (Tic Disorder)

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155 relevant articles (32 outcomes, 40 trials/studies) found for this Disease

Description: Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany general medical conditions. (From DSM-IV, 1994)

Also Known As:

Tic Disorder; Chronic Motor or Vocal Tic Disorder; Transient Tic Disorder; Tic Disorder, Transient; Childhood Tic Disorders; Motor Tic Disorders; Motor or Vocal Tic Disorder, Chronic; Tic Disorders, Childhood; Tic Disorders, Motor; Childhood Tic Disorder; Motor Tic Disorder; Post Traumatic Tic Disorder; Post-Traumatic Tic Disorders; Tic Disorder, Childhood; Tic Disorder, Motor; Tic Disorder, Post Traumatic; Tic Disorder, Vocal; Tic Disorders, Post-Traumatic; Tic Disorders, Transient; Transient Tic Disorders; Vocal Tic Disorder; Post-Traumatic Tic Disorder; Tic Disorder, Chronic Motor or Vocal; Tic Disorder, Post-Traumatic; Tic Disorders, Vocal; Vocal Tic Disorders

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3422

Central Nervous System Diseases: 931

Movement Disorders: 1473

Tic Disorders: 155

Tourette Syndrome: 847

Mental Disorders: 1709

Mental Disorders Diagnosed in Childhood

Tic Disorders: 155

Tourette Syndrome: 847

Related Diseases

1.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
2.	Tics (Tic)
3.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
4.	Tourette Syndrome (Tourette's Syndrome)
5.	Dyskinesias (Dyskinesia)

Experts

1.	Sverd, Jeffrey: 4 articles (09/2008 - 06/2002)
2.	Gadow, Kenneth D: 4 articles (09/2008 - 06/2002)
3.	Rothenberger, Aribert: 4 articles (06/2007 - 02/2007)
4.	Nolan, Edith E: 3 articles (09/2008 - 06/2002)
5.	Sprafkin, Joyce: 3 articles (09/2008 - 06/2002)
6.	Banaschewski, Tobias: 3 articles (06/2007 - 02/2007)
7.	Zhong, You-Quan: 2 articles (09/2008 - 10/2007)
8.	Schneider, Jayne: 2 articles (09/2008 - 07/2007)
9.	Roessner, Veit: 2 articles (06/2007 - 02/2007)
10.	Yu, De-Li: 1 article (09/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tic Disorders:

1.	Methylphenidate (Ritalin)FDA LinkGeneric 04/01/1999 - "CONCLUSIONS: Long-term treatment with methylphenidate seems to be safe and effective for the management of ADHD behaviors in many (but not necessarily all) children with mild to moderate tic disorder" 05/01/1992 - "In this study, 11 prepubertal hyperactive boys with tic disorder received placebo and three doses of methylphenidate (0.1, 0.3, and 0.5 mg/kg) for 2 weeks each, under double-blind conditions" 09/01/2008 - "Methylphenidate is an effective short-term treatment for oppositional behavior in children with comorbid ADHD and chronic multiple tic disorder." 07/01/2007 - "Immediate-release methylphenidate for ADHD in children with comorbid chronic multiple tic disorder." 04/01/1999 - "METHODS: Thirty-four prepubertal children with ADHD and chronic multiple tic disorder (who had participated in an 8-week, double-blind, placebo-controlled methylphenidate evaluation) were evaluated at 6-month intervals for 2 years as part of a prospective, nonblind, follow-up study" Order ALL the reference details at left...
2.	Risperidone (Risperdal Consta)FDA Link 09/01/1995 - "OBJECTIVE: The purpose of this trial was to investigate the short-term safety and efficacy of risperidone in the treatment of chronic tic disorders in children and adolescents" 11/01/2001 - "Risperidone has been proved on efficacy for tic disorders but EPS still remain, even though it was claimed to be less" 01/01/2003 - "Cases: "A" was an 8-year-old boy with attention deficit and chronic tic disorder who developed obsessive-compulsive symptoms within 2 weeks of starting risperidone" 09/01/1995 - "Risperidone treatment of children and adolescents with chronic tic disorders: a preliminary report." 11/01/2004 - "CONCLUSIONS: Risperidone may become the first-line drug in treatment of tic disorders and behaviour therapy might be increasingly used within a multimodal treatment program." Order ALL the reference details at left...
3.	Serotonin (5 Hydroxytryptamine)IBA 04/01/1994 - "CONCLUSIONS: The results of this study suggest that OCD patients with a comorbid chronic tic disorder constitute a clinically meaningful subtype of OCD that might require conjoint serotonin-uptake inhibitor/neuroleptic therapy for effective symptom reduction." 02/01/2007 - "Children and adolescents with obsessive-compulsive disorder and a comorbid tic disorder should begin treatment with cognitive-behavior therapy alone or the combination of cognitive-behavior therapy plus a serotonin reuptake inhibitor." 04/15/1991 - "Blood 5-HT content was not associated with a history of major depressive disorder or chronic tic disorder" 08/01/2000 - "BACKGROUND: To date, only 1 controlled study has found a drug (haloperidol) to be efficacious in augmenting response in patients with obsessive-compulsive disorder (OCD) refractory to serotonin reuptake inhibitor (SRI) monotherapy; patients with comorbid chronic tic disorders showed a preferential response" 10/01/1993 - "This retrospective case-controlled analysis evaluated treatment response to the serotonin reuptake inhibitor fluvoxamine in patients with obsessive-compulsive disorder (OCD), with or without a comorbid chronic tic disorder" Order ALL the reference details at left...
4.	Haloperidol (Haldol)FDA LinkGeneric 06/01/2004 - "Tic disorder was successfully treated with haloperidol" 04/01/1994 - "The haloperidol-treated group consisted of two women and 15 men, three inpatients and 14 outpatients, and seven patients with a comorbid chronic tic disorder" 04/01/1986 - "The patients were treated with haloperidol for their tic disorders, and concomitant with the reduction of the frequency and severity of tics was marked improvement in language" 11/01/1995 - "The addition of low-dose haloperidol and pimozide to ongoing SUI treatment has been shown to be effective in up to 65% of SUI-refractory OCD patients, particularly in those with comorbid chronic tic disorder" 03/01/1984 - "In a five-year study, 21 patients with multiple tic disorder intolerant of haloperidol therapy were treated with fluphenazine hydrochloride" Order ALL the reference details at left...
5.	Clonidine (ST 155)FDA LinkGeneric 09/01/2008 - "CONCLUSIONS: The clonidine adhesive patch is effective and safe for tic disorders." 03/01/1993 - "To examine the efficacy of clonidine in this population of children, the use of clonidine in the treatment of children with ADHD with and without comorbid tic disorders was examined in a retrospective chart review of 54 children over a 4-year period" 09/01/2008 - "OBJECTIVE: The aim of the present study was to evaluate the therapeutic effectiveness and safety of the clonidine adhesive patch in treating tic disorders" 10/01/2007 - "Randomized double-blind controlled study on treatment of tic disorders in children with transcutaneous patch of clonidine]" 09/01/2008 - "Randomized double-blind multicentre placebo-controlled clinical trial of the clonidine adhesive patch for the treatment of tic disorders." Order ALL the reference details at left...
6.	Fluvoxamine (Luvox)FDA LinkGeneric 04/01/2007 - "The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder" 10/01/1993 - "The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder." 10/01/1993 - "Thirty-three fluvoxamine-treated OCD patients with a concurrent chronic tic disorder were compared with 33 age- and sex-matched OCD patients without chronic tics who had received fluvoxamine treatment in the same setting during the same period of time and in a similar manner" 10/30/2000 - "The aim of this study was to investigate the efficacy and tolerability of olanzapine addition to fluvoxamine-refractory OCD patients and to assess if a comorbid chronic tic disorder or a concomitant schizotypal personality disorder was associated with response" 04/01/1994 - "Eight of eight patients with comorbid chronic tic disorders, such as Tourette's disorder, responded to double-blind haloperidol addition to ongoing fluvoxamine treatment" Order ALL the reference details at left...
7.	Dopamine (Intropin)FDA LinkGeneric 01/01/1986 - "The dopamine hypothesis of tic disorders is supported by this observation." 11/01/1983 - "Abnormalities of central nervous system dopamine metabolism may be involved in the pathophysiology of the tic disorders." 10/01/2004 - "Involuntary movements (dyskinesia) are a common symptom of dopamine-replacement therapy in parkinsonian patients, neuroleptic drug treatment of mental patients, and tic disorders" 12/01/1993 - "The addition of dopamine (DA) antagonists to the regimens of treatment-resistant patients appears to be a potentially useful strategy for the specific subgroup of OCD patients with a comorbid chronic tic disorder such as Tourette's syndrome" 05/01/1993 - "However, the addition of low-dose dopamine (DA) antagonists to the regimens of treatment-resistant patients appears to be a potentially useful strategy for the specific subgroup of OCD patients with a comorbid chronic tic disorder such as Tourette's syndrome" Order ALL the reference details at left...
8.	Guanfacine (Tenex)FDA LinkGeneric 07/01/2001 - "CONCLUSIONS: Guanfacine appears to be a safe and effective treatment for children with tic disorders and ADHD." 11/01/2005 - "CONCLUSION: Results of this open-label study add to the growing data base on the safety and efficacy of guanfacine in children with ADHD and tic disorders." 11/01/2005 - "An open-label, prospective study of guanfacine in children with ADHD and tic disorders." 07/01/2001 - "METHOD: Subjects from a specialty tic disorders clinic were randomly assigned to receive 8 weeks of treatment with guanfacine or placebo under double-blind conditions" 07/01/2001 - "OBJECTIVE: This study evaluated the efficacy and safety of guanfacine in treating children with tic disorders and attention deficit hyperactivity disorder (ADHD)" Order ALL the reference details at left...
9.	Intravenous Immunoglobulins (IVIG)FDA Link 05/01/2001 - "A recently completed placebo-controlled trial revealed that both IVIG and TPE were effective in reducing neuropsychiatric symptom severity (40% to 55% reductions, respectively) for a group of severely ill children with OCD and/or tic disorders" 04/01/2004 - "CONCLUSION: Based on the present results, IVIG cannot be recommended in tic disorders." 04/01/2004 - "METHOD: Thirty patients with a DSM-IV tic disorder were randomly assigned to IVIG (1 g/kg on 2 consecutive days; mean age = 28.71 years; range, 14-53 years) or placebo (mean age = 30.73 years; range, 14-63 years)" 04/01/2004 - "No data are available on the effectiveness of intravenous immunoglobulins (IVIG) on tic severity in unselected tic disorder patients" 10/02/1999 - "INTERPRETATION: Plasma exchange and IVIG were both effective in lessening of symptom severity for children with infection-triggered OCD and tic disorders" Order ALL the reference details at left...
10.	Desipramine (Pertofrane)FDA LinkGeneric 07/01/2002 - "To address this issue, we evaluated the tolerability and efficacy of the noradrenergic tricyclic antidepressant desipramine hydrochloride in the treatment of children and adolescents with chronic tic disorders and comorbid ADHD" 07/01/2002 - "CONCLUSIONS: Treatment with desipramine was well tolerated and was associated with robust clinically significant reductions in tic and ADHD symptoms in children and adolescents with chronic tic disorders and ADHD diagnoses." 07/01/2002 - "A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder." 03/01/1993 - "The purpose of this study was the examination of the efficacy of desipramine (DMI) in the treatment of pediatric patients with chronic tic disorder (CTD; TS or chronic motor tics) + attention-deficit hyperactivity disorder (ADHD)" 03/01/1993 - "Desipramine treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome." Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 08/01/2001 - "With regard to the treatment of tic disorders in children and adolescents, far more studies evaluated the efficacy of pharmacotherapy than of psychotherapy" 04/01/2008 - "The presence of tic disorders may also predict poorer response to pharmacotherapy in pediatric OCD" 03/01/1993 - "OBJECTIVE: Clonidine has been suggested as an alternative pharmacotherapy for patients with attention-deficit hyperactivity disorder (ADHD) and comorbid tic disorders" Order ALL the reference details at left...
2.	Plasma Exchange 10/02/1999 - "INTERPRETATION: Plasma exchange and IVIG were both effective in lessening of symptom severity for children with infection-triggered OCD and tic disorders" 10/02/1999 - "Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood." 10/02/1999 - "METHODS: Children with severe, infection-triggered exacerbations of obsessive-compulsive disorder (OCD) or tic disorders, including Tourette syndrome, were randomly assigned treatment with plasma exchange (five single-volume exchanges over 2 weeks), IVIG (1 g/kg daily on 2 consecutive days), or placebo (saline solution given in the same manner as IVIG)" Order ALL the reference details at left...
3.	Deep Brain Stimulation 11/01/2006 - "In response to recent publicity regarding the potential use of deep brain stimulation (DBS) for reducing tic severity in Tourette's syndrome (TS), the Tourette Syndrome Association convened a group of TS and DBS experts to develop recommendations to guide the early use and potential clinical trials of DBS for TS and other tic disorders" Order ALL the reference details at left...
4.	Tonsillectomy 09/01/2001 - "RESULTS: Two siblings, one with obsessive-compulsive disorder (OCD) and one with a tic disorder, had tonsillectomy for recurrent streptococcal pharyngitis" Order ALL the reference details at left...
5.	Sign Language 12/01/2001 - "His tic disorder rapidly accelerated from the age of seven over a six-month period and soon sign language was incorporated into tics as complex "vocal" tics" Order ALL the reference details at left...

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