Gold compounds inhibit adhesion of human cancer cells to vascular endothelial cells.

Abstract

Transcription factor NF-kappaB controls the expression of a number of genes including those for cell adhesion molecules such as E-selectin, ICAM-1 and VCAM-1. These cell adhesion molecules are known to play important roles in a critical step of tumor metastasis; the arrest of tumor cells on the venous or capillary bed of the target organ. NF-kappaB is activated by extracellular signals such as those elicited by the proinflammatory cytokines, TNF and IL-1. Here we demonstrate that IL-1beta induces nuclear translocation of NF-kappaB in human umbilical vein endothelial cells (HUVEC) followed by induction of cell surface expression of E-selectin, ICAM-1 and VCAM-1, and subsequently augments adhesion of cancer cells expressing sialyl Lewis antigen, a ligand of E-selectin. We also demonstrated that the adhesion of tumor cells to IL-1beta-treated HUVEC was inhibited by gold compounds such as aurothioglucose and aurothiomalate. These observations indicate the involvement of NF-kappaB in cancer metastasis and suggest the feasibility of using gold compounds to prevent metastasis.

• Authors: Keiichi Tozawa, Noriyasu Kawai, Yutaro Hayashi, Shoichi Sasaki, Kenjiro Kohri, Takashi Okamoto
• Journal: Cancer letters (Cancer Lett) Vol. 196 Issue 1 Pg. 93-100 (Jun 30 2003) ISSN: 0304-3835 [Print] Ireland
• PMID: 12860295 (Publication Type: Journal Article)

Chemical References

• Cell Adhesion Molecules
• E-Selectin
• Gold Compounds
• Interleukin-1
• NF-kappa B
• Vascular Cell Adhesion Molecule-1
• Intercellular Adhesion Molecule-1

Topics

• Cell Adhesion
• Cell Adhesion Molecules (metabolism)
• Cell Line
• E-Selectin (metabolism)
• Endothelium, Vascular (metabolism)
• Gold Compounds (pharmacology)
• Humans
• Intercellular Adhesion Molecule-1 (metabolism)
• Interleukin-1 (pharmacology)
• NF-kappa B (metabolism)
• Neoplasms (metabolism)
• Tumor Cells, Cultured
• Umbilical Veins
• Vascular Cell Adhesion Molecule-1 (metabolism)