Tuberculous epididymo-orchitis following intravesical BCG for superficial bladder cancer.

Abstract

A seventy-two-year-old man with transitional cell carcinoma of the bladder received intravesical Bacillus Calmette-Guérin (BCG) following which he developed left testicular pain and swelling that partially resolved with conservative treatment. Six months later a second course of BCG was given for recurrent disease. Ten months later, he developed left testicular swelling and severe induration along with a draining scrotal sinus. Tuberculous orchitis was suspected and a left orchiectomy was performed. Pathology showed caseating granulomatous orchitis and epididymitis with numerous acid fast bacilli on Ziehl-Neelson stain. The patient received a six-month course of antituberculous therapy. This case highlights a rare but serious complication of intravesical BCG.

• Authors: Muhammad A Bulbul, Adonis Hijaz, Mona Beaini, George F Araj, Ayman Tawil
• Journal: Le Journal medical libanais. The Lebanese medical journal (J Med Liban) 2002 Jan-Apr Vol. 50 Issue 1-2 Pg. 67-9 ISSN: 0023-9852 [Print] Lebanon
• PMID: 12841318 (Publication Type: Journal Article)

Chemical References

• BCG Vaccine

Topics

• Administration, Intravesical
• Aged
• BCG Vaccine (adverse effects, therapeutic use)
• Carcinoma, Transitional Cell (drug therapy)
• Epididymitis (etiology)
• Humans
• Male
• Orchitis (etiology)
• Tuberculosis, Male Genital (etiology)
• Urinary Bladder Neoplasms (drug therapy)