Kinetics of the production of serum antibody levels and Th1 (IL-2, IFN-gamma) and Th2 (IL-4, IL-10)
cytokines was studied in five pigs vaccinated with a synthetic tri-
peptide vaccine (S3Pvac) against Taenia solium, a
vaccine that has been shown protects pigs against naturally acquired
infection. Healthy pigs of mixed genetic background, similar to those bred in rural villages of Mexico, were vaccinated with S3Pvac or with adjuvant alone, kept in sanitary conditions and bled at different times after vaccination to study the development of their specific immune response. Peripheral blood mononuclear cells (PBMCs) of vaccinated pigs showed a significant increment in the production of Th1
cytokines (IL-2 and IFN-gamma) but not of Th2
cytokines (IL-4 and IL-10) after specific PBLs stimulation with all the individual
peptides. A Th1-inclined
cytokine profile leading to an exacerbated local
inflammation at the early installation stage of the cysticercus may possibly interfere with their successful establishment in the serum
antibodies against total cysticercus
antigens and against each of the three different
peptides comprising S3Pvac were detected 7-51 days after vaccination.
Antibodies against GK-1 interfered with the cysticerci development into intestinal tapeworms in
prednisolone-treated hamsters. The sub-lethal crippling effect of anti-GK-1
antibodies upon cysticerci indicates to a therapeutic application of S3Pvac in infected pigs having potential epidemiological consequences, as it could aid in decreasing the number of tapeworms expected to develop from the few cysticerci that survive in the vaccinated pigs.