Abstract | BACKGROUND: METHODS AND RESULTS: ProBNP levels were measured in 73 patients with acute PE within 4 hours of admission. Adverse clinical outcome was defined as in-hospital death or the need for at least 1 of the following: cardiopulmonary resuscitation, mechanical ventilation, pressors, thrombolysis, catheter fragmentation, or surgical embolectomy. In the 53 patients with a benign clinical outcome, proBNP (median 121, range 16 to 34 802 pg/mL) was lower than in 20 patients with adverse clinical outcome (median 4250, range 92 to 49 607 pg/mL; P<0.0001). The negative predictive value of proBNP levels <500 pg/mL to predict adverse clinical outcome was 97% (95% confidence interval 84 to 99). ProBNP remained an independent predictor for adverse clinical outcome (odds ratio 14.6; 95% confidence interval 1.5 to 139.0; P=0.02) after adjusting for severity of PE (submassive/massive), troponin T levels >0.01 ng/mL, age >70 years, gender, and history of congestive heart failure. CONCLUSIONS: Low proBNP levels predict an uneventful hospital course in patients with acute PE. A proBNP level <500 pg/mL identifies patients who will be potential candidates for an abbreviated hospital length of stay or care on a completely outpatient basis.
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Authors | Nils Kucher, Gert Printzen, Tanja Doernhoefer, Stephan Windecker, Bernhard Meier, Otto Martin Hess |
Journal | Circulation
(Circulation)
Vol. 107
Issue 12
Pg. 1576-8
(Apr 01 2003)
ISSN: 1524-4539 [Electronic] United States |
PMID | 12668488
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Nerve Tissue Proteins
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Acute Disease
- Aged
- Biomarkers
(blood)
- Female
- Humans
- Male
- Middle Aged
- Natriuretic Peptide, Brain
- Nerve Tissue Proteins
(blood)
- Peptide Fragments
(blood)
- Prognosis
- Pulmonary Embolism
(diagnosis)
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