Antioxidant Effect of D-002 on Gastric Mucosa of Rats with Experimentally Induced Injury.

Abstract

D-002 is a natural mixture of higher aliphatic primary alcohols isolated from beeswax that has antioxidant and antiulcer properties. Because the role of lipid peroxidation in gastric damage is well recognized, this work was designed to investigate the possible effect of D-002 on lipid peroxidation in gastric mucosa in two experimental models of gastric injury in rats: (1) gastric ulcer induced by indomethacin and (2) mucosal injury induced by ischemia-reperfusion (I-R). The results demonstrated a remarkable protective effect of D-002 on lipid peroxidation in gastric ulcer induced by indomethacin and a moderate protective effect of D-002 on gastric erosions and lipid peroxidation induced by I-R.

• Authors: Vivian Molina, Suria Valdés, Daisy Carbajal, Lourdes Arruzazabala, Roberto Menéndez, Rosa Más
• Journal: Journal of medicinal food (J Med Food) Vol. 4 Issue 2 Pg. 79-83 ( 2001) ISSN: 1557-7600 [Electronic] United States
• PMID: 12639416 (Publication Type: Journal Article)