D 002

01/01/2005 - "Treatments with D-002 at 50, 100, and 200 mg/kg or vehicle were administered 3 hours after ulcer induction. "
08/01/1996 - "This study was designed to determine if D-002 shows cytoprotective properties on gastric mucosa in ethanol-induced ulcers. "
05/01/2001 - "D-002 is a mixture of high-molecular-weight aliphatic alcohols, obtained from bees wax (Apis mellifera), with mild anti-inflammatory properties and effective anti-ulcer activities demonstrated in experimental models. "
10/01/2000 - "Effect of D-002 on gastric mucus composition in ethanol-induced ulcer."
08/01/1996 - "D-002 (5 and 25 mg kg-1) administered to normal rats significantly increased the soluble mucus content and also prevented its reduction in rats with ethanol-induced ulcers. "

03/01/2015 - "Early results found that D-002 was effective in the cotton pellet-induced granuloma and carrageenan-induced pleurisy model in rats, lowering pleural leukotriene B4 levels without causing gastrointestinal ulceration. "
04/01/2011 - "D-002, a mixture of six higher aliphatic alcohols purified from beeswax, displayed anti-inflammatory effects in carrageenan-induced pleurisy and cotton pellet granuloma in rats. "
05/01/1998 - "D-002 is a natural mixture of higher aliphatic primary alcohols, isolated and purified from beeswax which has anti-inflammatory properties, reduces leukotrienes (LTB4) and thromboxane B2 (TXB2) in exudated carrageenan-induced pleurisy, and has anti-ulcer activity in different experimental models. "

10/01/1998 - "D-002 (25, 50 and 200 mg/kg) also significantly diminished the granuloma weight in the cotton pellet granuloma in rats. "
03/01/2015 - "Early results found that D-002 was effective in the cotton pellet-induced granuloma and carrageenan-induced pleurisy model in rats, lowering pleural leukotriene B4 levels without causing gastrointestinal ulceration. "
04/01/2011 - "D-002, a mixture of six higher aliphatic alcohols purified from beeswax, displayed anti-inflammatory effects in carrageenan-induced pleurisy and cotton pellet granuloma in rats. "

03/01/2015 - "However, D-002 effects on inflammation received little attention for years. "
10/01/1998 - "D-002 administered orally to rats (100 and 200 mg/kg) produced a mild but significant reduction of exudate volume in carrageenan-induced pleuritic inflammation that was accompanied by a marked and significant decrease of leukotriene B4 (LTB4) levels in the exudate. "

07/01/2013 - "Fifty patients with NAFLD were randomized to receive a placebo or D-002 (100 mg/day) for 24 weeks. "
07/01/2013 - "D-002 (100 mg/day) improved ultrasonographic findings, indicators of insulin resistance, plasma TAS and clinical evolution on NAFLD patients. "
07/01/2013 - "Effects of D-002, a mixture of high molecular weight beeswax alcohols, on patients with nonalcoholic fatty liver disease."