Evaluation of 5-S-cysteinyldopa as a marker of melanoma progression: 10 years' experience.

Abstract

5-S-Cysteinyldopa (5-S-CD) has been used as a biochemical marker of melanoma progression. In this study, we measured serum levels of 5-S-CD in 2648 samples taken from 218 patients in order to evaluate the usefulness of this parameter in following melanoma progression and prognosis. 5-S-CD levels were significantly elevated above the upper limit of the normal range (10 nmol/l) in stage IV melanoma patients. The sensitivity of elevated serum 5-S-CD levels in detecting distant metastasis was 73%, while the specificity was 98% and the positive predictive value 94%. The sensitivity was improved to 77% when cases of amelanotic melanoma were excluded. Patients without metastases had elevated 5-S-CD values in 5% of the 1480 serum samples. Changes in serum 5-S-CD levels were followed during disease progression until the end stage in 49 patients. In 33% of the patients, elevation of serum 5-S-CD levels preceded clinical detection of visceral metastases, and in 37% elevation of 5-S-CD levels occurred at the same time as visceral metastasis. Patients with elevated 5-S-CD levels before or after surgical treatment had significantly shorter survival times than those with normal levels. These results show that the level of 5-S-CD in the serum is a sensitive and specific marker in predicting distant metastases. Elevated serum levels of 5-S-CD, before or after surgical treatment, is associated with a poor prognosis.

• Authors: K Wakamatsu, T Kageshita, M Furue, N Hatta, Y Kiyohara, J Nakayama, T Ono, T Saida, M Takata, T Tsuchida, H Uhara, A Yamamoto, N Yamazaki, A Naito, S Ito
• Journal: Melanoma research (Melanoma Res) Vol. 12 Issue 3 Pg. 245-53 (Jun 2002) ISSN: 0960-8931 [Print] England
• PMID: 12140381 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Cysteinyldopa

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (blood)
• Child
• Cysteinyldopa (blood)
• Disease Progression
• Eye Neoplasms (blood, mortality, pathology, therapy)
• Female
• Follow-Up Studies
• Humans
• Japan (epidemiology)
• Life Tables
• Male
• Melanoma (blood, mortality, pathology, therapy)
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Staging
• Prognosis
• Sensitivity and Specificity
• Skin Neoplasms (blood, mortality, pathology, therapy)
• Survival Analysis