Abstract | OBJECTIVE: DESIGN: METHODS: Serum AHSG was determined by radial immunodiffusion. RESULTS: Compared to controls, significantly lower AHSG levels were found in patients with liver cirrhosis and hepatocellular cancer but not the acute viral hepatitides. Strong positive correlation with serum transferrin, albumin and prothrombin was found. Febrile episodes were not associated with significantly decreased AHSG levels. Concentrations below 300 microg/ml were associated with high mortality rate (52.0%; relative risk, 5.497; 95% confidence interval, 2.472-12.23; P < 0.0001). Of all laboratory parameters studied serum AHSG levels showed the greatest difference between deceased and survived patients with cirrhosis and cancer. Moreover, other acute phase reactants did not differ significantly. The multiple logistic regression analysis indicated that the decrease of serum AHSG is independent of all other variables that were found decreased in deceased patients. CONCLUSIONS:
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Authors | László Kalabay, Lajos Jakab, Zoltán Prohászka, George Füst, Zsuzsa Benkö, László Telegdy, Zsolt Lörincz, Péter Závodszky, Philippe Arnaud, Béla Fekete |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 14
Issue 4
Pg. 389-94
(Apr 2002)
ISSN: 0954-691X [Print] England |
PMID | 11943951
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- AHSG protein, human
- Blood Proteins
- Cystatins
- Transferrin
- alpha-2-HS-Glycoprotein
- alpha-Fetoproteins
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Topics |
- Acute-Phase Reaction
(blood)
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Blood Proteins
- Cystatins
(blood)
- Female
- Humans
- Immunodiffusion
- Liver Cirrhosis
(blood, mortality)
- Liver Function Tests
- Liver Neoplasms
(blood, mortality)
- Logistic Models
- Male
- Middle Aged
- Transferrin
(analysis)
- alpha-2-HS-Glycoprotein
- alpha-Fetoproteins
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