Prothrombin (Factor II)

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2833 relevant articles (50 outcomes, 245 trials/studies) found for this Bio-Agent

Description: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.

Also Known As:

Factor II; Blood Coagulation Factor II; Differentiation Reversal Factor; Factor II, Coagulation; Factor, Differentiation Reversal; II, Coagulation Factor; Coagulation Factor II; Blood-coagulation factor II

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1

Enzyme Precursors: 134

Prothrombin: 2833

acarboxyprothrombin: 505

prothrombin fragment 1: 99

prothrombin fragment 1.2: 15

prothrombin Tokushima: 2

factor II clotting antigen: 1

prothrombin Barcelona: 1

prothrombin habana: 1

prothrombin Magdeburg: 1

prothrombin Metz: 1

trocarin: 1

acetylcysteinyl-leucyl-glutamyl-glutamyl-prolyl-cysteine methyl ester cyclic disulfide

chemotactic peptide CB67-129

cysteinyl-leucyl-glutamyl-glutamyl-prolyl-cysteine cyclic disulfide

prothrombin (des 1-44)

prothrombin activator (Taipan venom)

prothrombin Clamart

prothrombin fragment 1.2.3

prothrombin fragment 2

prothrombin Frankfurt

prothrombin Greenville

prothrombin Himi

prothrombin Perija

prothrombin Poissy

prothrombin precursor (13-29)

prothrombin residue (1-39)

prothrombin Salakta

prothrombin San Antonio

prothrombin Scranton

prothrombin type 3

Protromplex

Trp(4)- prothrombin (1-46)

Amino Acids, Peptides, and Proteins

Proteins: 58433

Blood Proteins: 3862

Blood Coagulation Factors: 1580

Prothrombin: 2833

acarboxyprothrombin: 505

prothrombin fragment 1: 99

prothrombin fragment 1.2: 15

prothrombin Tokushima: 2

factor II clotting antigen: 1

prothrombin Barcelona: 1

prothrombin habana: 1

prothrombin Magdeburg: 1

prothrombin Metz: 1

trocarin: 1

acetylcysteinyl-leucyl-glutamyl-glutamyl-prolyl-cysteine methyl ester cyclic disulfide

chemotactic peptide CB67-129

cysteinyl-leucyl-glutamyl-glutamyl-prolyl-cysteine cyclic disulfide

prothrombin (des 1-44)

prothrombin activator (Taipan venom)

prothrombin Clamart

prothrombin fragment 1.2.3

prothrombin fragment 2

prothrombin Frankfurt

prothrombin Greenville

prothrombin Himi

prothrombin Perija

prothrombin Poissy

prothrombin precursor (13-29)

prothrombin residue (1-39)

prothrombin Salakta

prothrombin San Antonio

prothrombin Scranton

prothrombin type 3

Protromplex

Trp(4)- prothrombin (1-46)

Biological Factors: 931

Blood Coagulation Factors: 1580

Prothrombin: 2833

acarboxyprothrombin: 505

prothrombin fragment 1: 99

prothrombin fragment 1.2: 15

prothrombin Tokushima: 2

factor II clotting antigen: 1

prothrombin Barcelona: 1

prothrombin habana: 1

prothrombin Magdeburg: 1

prothrombin Metz: 1

trocarin: 1

acetylcysteinyl-leucyl-glutamyl-glutamyl-prolyl-cysteine methyl ester cyclic disulfide

chemotactic peptide CB67-129

cysteinyl-leucyl-glutamyl-glutamyl-prolyl-cysteine cyclic disulfide

prothrombin (des 1-44)

prothrombin activator (Taipan venom)

prothrombin Clamart

prothrombin fragment 1.2.3

prothrombin fragment 2

prothrombin Frankfurt

prothrombin Greenville

prothrombin Himi

prothrombin Perija

prothrombin Poissy

prothrombin precursor (13-29)

prothrombin residue (1-39)

prothrombin Salakta

prothrombin San Antonio

prothrombin Scranton

prothrombin type 3

Protromplex

Trp(4)- prothrombin (1-46)

Experts

1.	De Stefano, V: 11 articles (03/2008 - 07/2000)
2.	Vayá, A: 8 articles (11/2001 - 01/2000)
3.	Almawi, Wassim Y: 7 articles (08/2006 - 10/2002)
4.	Mira, Y: 7 articles (11/2001 - 01/2000)
5.	Aznar, J: 7 articles (11/2001 - 01/2000)
6.	Mannucci, P M: 6 articles (03/2008 - 12/2000)
7.	Margaglione, M: 6 articles (11/2007 - 12/2000)
8.	Finan, Ramzi R: 6 articles (09/2005 - 10/2002)
9.	Villa, P: 6 articles (11/2001 - 04/2000)
10.	Estellés, A: 6 articles (11/2001 - 01/2000)

Related Diseases

1.	Hemorrhage 01/01/2003 - "He had been managed during his bleeding episodes with prothrombin complex factor concentrates, which became less effective in controlling his bleeding. " 08/01/1991 - "His prothrombin time, activated partial thromboplastin time and prothrombin activity improved promptly and his bleeding ceased. " 06/01/1984 - "Although treatment of bleeding complications has been improved with the introduction of an activated prothrombin complex preparation, therapy remains unsatisfactory. " 01/01/2008 - "Preoperative laboratory studies to be performed include Hb%, blood counts including platelet counts, bleeding and clotting time (or prothrombin and activated partial thromboplastin time) and blood chemistry profile; ECG is advisable. " 01/01/2008 - "Preoperative laboratory studies include hemogram including platelet counts, bleeding and clotting time (or prothrombin and activated partial thromboplastin time), and blood chemistry profile. " Order ALL the reference details at left...
2.	Hemophilia A (Haemophilia) 01/01/1950 - "Studies on serum prothrombin in hemophilia." 11/01/2008 - "Activated prothrombin complex concentrate (aPCC) has been used in more than 70 haemophilia patients with inhibitors in different clinical situations. " 02/01/2007 - "Regular self-infusion of an activated prothrombin complex concentrate (APCC) has been successfully introduced to a 14-year-old boy with hemophilia A. " 03/01/2002 - "The prothrombin 20210A allele influences clinical manifestations of hemophilia A in patients with intron 22 inversion and without inhibitors." 01/01/1990 - "[Activated prothrombin complex preparations for the treatment of anticoagulant hemophilia. " Order ALL the reference details at left...
3.	Thrombosis (Thrombus) 05/01/2000 - "Additionally, a bivariate linkage analysis of plasma prothrombin activity and thrombosis significantly improved the linkage signal for prothrombin activity (lod score = 4.7; P = 1.5 x 10(-6)) and provided strong evidence that this QTL has a pleiotropic effect on the risk of thrombosis (lod score = 2.43; P =.0004). " 04/01/2006 - "When studies from Turkey were excluded from the meta-analysis, only the prothrombin G20210A mutation was associated with thrombosis." 01/01/2006 - "Mutation screening studies related with thrombosis revealed that prothrombin 20210A allele of the prothrombin gene leads to an increase in plasma prothrombin levels. " 03/01/2005 - "The third paper describes a knockdown of prothrombin in zebrafish, which recapitulates knockout studies in mouse, and marks the beginning of studies in the hemostasis and thrombosis area by this new knockdown technology. " 09/15/2000 - "Therefore, further studies are needed to determine which factors apart from the known G20210A polymorphism regulate prothrombin concentration and/or activity and may trigger the manifestation of thrombosis." Order ALL the reference details at left...
4.	Liver Diseases (Liver Disease) 10/01/2009 - "Liver function improved as verified by the Model for End-Stage Liver Disease score, which decreased from 17.9+/-5.6 to 10.7+/-6.3 (P<0.05) and prothrombin complex from international normalized ratio 1.9+/-0.4 to 1.4+/-0.5 (P<0.05). " 06/01/1969 - "[Triple biological test in the diagnosis of certain liver diseases (combined study of prothrombin, fibrinolytic and alexic studies)]" 10/01/2008 - "We conclude that serum Se levels are low in alcoholics; these low values depend more heavily on impaired nutrition but also on liver dysfunction; although low Se levels were associated with a higher mortality, prothrombin activity displaced serum Se when survival was assessed using Cox's regression model." 12/01/2007 - "Therapy with prothrombin-complex concentrate is seldom pursued in patients with liver disease due to high risk of thrombotic complications. " 07/01/2007 - "Postoperative liver dysfunction was defined as an international prothrombin ratio of > or = 1.5. " Order ALL the reference details at left...
5.	Hypoprothrombinemias (Prothrombin Deficiency) 02/01/1997 - "The probable cause for the severe hypoprothrombinemia was clearance of prothrombin-antibody complexes from the circulation. " 01/15/1990 - "The prothrombin survival time indicates that the hypoprothrombinemia is due to the clearance of the prothrombin-antiprothrombin complex in vivo." 12/01/2000 - "In this study, 13 patients with prothrombin deficiency were screened for the presence of alterations in the prothrombin gene, and nine novel candidate mutations were identified. " 11/01/2008 - "Prothrombin (factor II) deficiency is a rare autosomal recessive coagulation disorder that occurs in approximately 1 in 1-2 million people. " 12/01/2006 - "Severe prothrombin deficiency caused by prothrombin-Edmonton (R-4Q) combined with a previously undetected deletion." Order ALL the reference details at left...

Related Drugs and Biologics

1.	factor V Leiden
2.	Bilirubin
3.	recombinant FVIIa (rFVIIa)
4.	Factor V (Coagulation Factor V)
5.	Factor VIII (Coagulation Factor VIII)
6.	Factor VIIa (Activated Factor VII)
7.	Antibodies
8.	Thromboplastin (Tissue Factor)
9.	Serum Albumin
10.	fibrin fragment D (D-dimer)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
3.	Arthroplasty
4.	Aftercare (After-Treatment)
5.	Tonsillectomy

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