Abstract | BACKGROUND AND AIMS: METHODS: Experiments were conducted using three human liver cancer cell lines, PLC/PRF/5, Hep G2 and HuH-7, in vitro. These cells were exposed to troglitazone, a synthetic ligand for PPARgamma, and the effects on cell growth were analysed. RESULTS: CONCLUSION:
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Authors | M Toyoda, H Takagi, N Horiguchi, S Kakizaki, K Sato, H Takayama, M Mori |
Journal | Gut
(Gut)
Vol. 50
Issue 4
Pg. 563-7
(Apr 2002)
ISSN: 0017-5749 [Print] England |
PMID | 11889080
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Chromans
- Receptors, Cytoplasmic and Nuclear
- Thiazoles
- Thiazolidinediones
- Transcription Factors
- Caspases
- Troglitazone
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Topics |
- Antineoplastic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Blotting, Western
- Carcinoma, Hepatocellular
(pathology, therapy)
- Caspases
(metabolism)
- Cell Division
(drug effects)
- Chromans
(pharmacology)
- DNA Fragmentation
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay
(methods)
- Humans
- Liver Neoplasms
(pathology, therapy)
- Receptors, Cytoplasmic and Nuclear
(metabolism)
- Thiazoles
(pharmacology)
- Thiazolidinediones
- Transcription Factors
(metabolism)
- Troglitazone
- Tumor Cells, Cultured
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