Abstract | BACKGROUND: METHODS: The expression of MGMT was immunohistochemically evaluated in 60, 62, 105, and 46 paraffin-embedded samples from patients with curatively resected hepatocellular, gastric, colorectal, and breast cancers, respectively. RESULTS: The expression of MGMT was a positive predictive factor for overall survival in hepatocellular (P = .005) and gastric cancers (P < .001) and for relapse-free survival in breast cancers (P < .001). MGMT-positive gastric tumors (n = 42) were correlated with the absence of serosal invasion (P = .045), lymph node metastasis (P = .006), intestinal type (P = .018), and low pathological tumor, node, metastasis stage (P < .001). All breast tumors that recurred locally after operation were MGMT negative (P = .004). The clinicopathologic characteristics of colorectal cancers with respect to MGMT expression did not significantly differ. CONCLUSIONS: The expression of MGMT is a predictive prognostic marker in patients with hepatocellular, gastric, and breast cancers. These findings may help to establish therapeutic strategies for patients with these types of solid cancer.
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Authors | S Matsukura, K Miyazaki, H Yakushiji, A Ogawa, K Harimaya, Y Nakabeppu, M Sekiguchi |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 8
Issue 10
Pg. 807-16
(Dec 2001)
ISSN: 1068-9265 [Print] United States |
PMID | 11776495
(Publication Type: Journal Article)
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Chemical References |
- Neoplasm Proteins
- O(6)-Methylguanine-DNA Methyltransferase
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Topics |
- Aged
- Analysis of Variance
- Breast Neoplasms
(enzymology)
- Colorectal Neoplasms
(enzymology)
- Female
- Humans
- Immunohistochemistry
(methods)
- Liver Neoplasms
(enzymology)
- Male
- Middle Aged
- Neoplasm Proteins
(analysis)
- O(6)-Methylguanine-DNA Methyltransferase
(analysis)
- Prognosis
- Stomach Neoplasms
(enzymology)
- Survival Analysis
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