Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium).

Abstract

The activity of CVT-E002, an aqueous extract containing mainly oligosaccharides and polysaccharides from North American ginseng (Panax quinquefolium), as an immunobooster on murine spleen cells and peritoneal macrophages, was studied in-vitro. CVT-E002 stimulated the proliferation of normal mouse spleen cells, of which the major responding subpopulation was identified as B lymphocytes. CVT-E002 also activated peritoneal exudate macrophages leading to enhanced interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) production. In addition, CVT-E002 stimulated in-vivo immunoglobulin G (IgG) production in treated mice. These results identify some of the immunomodulating activities of CVT-E002 and suggest its use clinically for the modulation of immune responses.

• Authors: M Wang, L J Guilbert, L Ling, J Li, Y Wu, S Xu, P Pang, J J Shan
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 53 Issue 11 Pg. 1515-23 (Nov 2001) ISSN: 0022-3573 [Print] England
• PMID: 11732754 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Immunoglobulin G
• Interleukin-1
• Interleukin-6
• Plant Extracts
• Tumor Necrosis Factor-alpha
• Nitric Oxide

Topics

• Adjuvants, Immunologic (pharmacology)
• Animals
• Cell Division (drug effects)
• Dose-Response Relationship, Drug
• Immunity, Innate (drug effects)
• Immunoglobulin G (blood, drug effects)
• Interleukin-1 (metabolism)
• Interleukin-6 (metabolism)
• Macrophages (drug effects, metabolism)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Nitric Oxide (metabolism)
• Panax (chemistry)
• Plant Extracts (pharmacology)
• Spleen (cytology, drug effects)
• Tumor Necrosis Factor-alpha (metabolism)