Abstract |
39 patients with active knee osteoarthrosis, chosen according to ACR criteria, were assigned to receive flurbiprofen (n 12, 2 x 100 mg), tiaprofenic acid (n 14, 2 x 300 mg) and placebo (n 13) in a 3-week, placebo-controlled study. All patients completed the study, and both medications were found to be effective: improvement occurred in the clinical signs. These drugs reduced the TNF-alpha levels. Flurbiprofen especially affected the IL-6 levels. Our findings indicate that NSAIDs may be effective in the etiopathogenesis of osteoarthrosis.
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Authors | H Uzun, S Tuzun, N Ozaras, S Aydin, R Ozaras, S Dondurmaci, F Tuzun |
Journal | Acta orthopaedica Scandinavica
(Acta Orthop Scand)
Vol. 72
Issue 5
Pg. 499-502
(Oct 2001)
ISSN: 0001-6470 [Print] England |
PMID | 11728078
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Cytokines
- Interleukin-1
- Interleukin-6
- Propionates
- Tumor Necrosis Factor-alpha
- tiaprofenic acid
- Flurbiprofen
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Topics |
- Adult
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Cytokines
(blood)
- Female
- Flurbiprofen
(therapeutic use)
- Humans
- Interleukin-1
(blood)
- Interleukin-6
(blood)
- Male
- Middle Aged
- Osteoarthritis, Knee
(blood, drug therapy)
- Pain Measurement
- Propionates
(therapeutic use)
- Prospective Studies
- Tumor Necrosis Factor-alpha
(analysis)
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