Primary effusion lymphoma with herpesvirus 8 DNA in patients coinfected with HIV and hepatitis C virus: a report of 2 cases.

Abstract

The primary effusion lymphoma (PEL), commonly described in patients with AIDS, is a unique subset of diffuse large cell lymphoma in which the malignant lymphocytes proliferate exclusively in serous cavities. The cytologic, immunophenotypic, and molecular features of PEL are presented from findings of 2 patients coinfected with HIV and hepatitis C virus who presented with abdominal pain. Abdominal radiography in both patients displayed marked peritoneal effusions. Cytomorphologic examination of peritoneal fluid revealed a malignant lymphoma in both. Their immunophenotypic expression was CD30 (Ki-1) and epithelial membrane antigen. Molecular analysis demonstrated human herpesvirus 8 DNA in both patients and bcl-2 oncogene rearrangement within the major breakpoint region of t(14;18) chromosome translocation in Case B only. Clinical correlation supports the current concept that PEL represents a primary HIV/AIDS-related lymphoma in effusion. Cytomorphologic examination of body cavity fluid serves as a tool for the initial diagnosis of PEL.

• Authors: S Hong, A E Krafft
• Journal: The AIDS reader (AIDS Read) Vol. 11 Issue 8 Pg. 418-22 (Aug 2001) ISSN: 1053-0894 [Print] United States
• PMID: 11570267 (Publication Type: Case Reports, Journal Article)

Chemical References

• DNA, Viral

Topics

• Adult
• Ascitic Fluid (virology)
• DNA, Viral (analysis)
• Female
• HIV Infections (complications, virology)
• Hepatitis C (complications, virology)
• Herpesviridae Infections (complications, virology)
• Herpesvirus 8, Human (classification, genetics, immunology)
• Humans
• Immunophenotyping
• Lymphoma, AIDS-Related (pathology, virology)
• Male
• Middle Aged