Abstract |
This investigation considered whether defects in insulin secretion and insulin action may result in the development of sustained hyperglycemia induced by refeeding standard chow pellets. Hyperglycemia, sustained for 36 h was induced, in mice that ate standard chow pellets ad libitum after 48 h fasting, but not 24 h fasting. In 48 h-fasted mice, serum insulin levels were remarkably low and the ability of insulin secretion to respond to glucose was decreased, although insulin-stimulated glucose disposal was not impaired. However, hyperinsulinemia was observed after refeeding for 12 h. The 12 h-refed mice had impaired glucose tolerance and were remarkably insulin resistant. These results suggest that hyperglycemia induced by the fasting-refeeding was caused by hyperphagia and the failure of insulin secretion, and maintained the resulting induced insulin resistance.
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Authors | T Maeda, R Sakita, T Kaihatsu, M Miwa |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 24
Issue 8
Pg. 950-3
(Aug 2001)
ISSN: 0918-6158 [Print] Japan |
PMID | 11510492
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Insulin
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Topics |
- Animals
- Blood Glucose
(metabolism)
- Fasting
(physiology)
- Glucose Tolerance Test
- Hyperglycemia
(blood)
- Hypoglycemic Agents
(pharmacology)
- Insulin
(pharmacology)
- Insulin Resistance
(physiology)
- Male
- Mice
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