Abstract | BACKGROUND: Aberrations in chromosome 17 are important in carcinogenesis. We recently reported that numerical aberrations in chromosome 17 were associated with tumor progression in gastric cancer. The aim of this study was to determine the biological characteristics of gastric tumor cells with chromosome 17 numerical aberrations. METHODS: RESULTS: The frequency of Group 1 cells correlated with lymphatic invasion (P < .0001), lymph node metastasis (P < .0001), and venous invasion (P < .01). The frequency of these cells in gastric lesions was lower than in metastatic lymph nodes (P < .01). Logistic regression analysis identified the depth of invasion followed by the frequency of Group 1 cells were two of the most significant independent factors that could predict lymph node metastasis and lymphatic invasion. CONCLUSIONS:
|
Authors | R Terada, T Yasutake, S Nakamura, T Hisamatsu, T Nakagoe, H Ayabe, Y Tagawa |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 8
Issue 6
Pg. 525-32
(Jul 2001)
ISSN: 1068-9265 [Print] United States |
PMID | 11456052
(Publication Type: Evaluation Study, Journal Article)
|
Chemical References |
- Proliferating Cell Nuclear Antigen
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Chromosome Aberrations
- Chromosomes, Human, Pair 17
(genetics)
- Female
- Humans
- In Situ Hybridization, Fluorescence
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Metastasis
- Prognosis
- Proliferating Cell Nuclear Antigen
(analysis)
- Stomach Neoplasms
(genetics, pathology)
|