Abstract | BACKGROUND: METHODS: Serum nitrate levels were assessed in relation to the skin scores in 88 patients with atopic dermatitis (AD) (aged 0.4-8 years: mean+/-SD, 2.2+/-1.9, 41 boys and 47 girls) and 12 nonatopic children (aged 0.8-4 years: mean+/-SD, 1.8+/-0.9, seven boys and five girls). RESULTS: Serum nitrate levels of patients with AD were significantly increased as compared to nonatopic controls and were also correlated with the disease severity. The skin scores were significantly correlated with serum nitrate levels as well as peripheral eosinophil counts. CONCLUSION: Our results indicate that nitric oxide may be involved in the pathogenesis of vasodilation and erythema in AD skin.
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Authors | S Taniuchi, T Kojima, K Hara Mt, A Yamamoto, M Sasai, H Takahashi, Y Kobayashi |
Journal | Allergy
(Allergy)
Vol. 56
Issue 7
Pg. 693-5
(Jul 2001)
ISSN: 0105-4538 [Print] Denmark |
PMID | 11421931
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Emollients
- Nitrates
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Topics |
- Administration, Topical
- Anti-Inflammatory Agents
(pharmacology)
- Child
- Child Welfare
- Child, Preschool
- Dermatitis, Atopic
(blood)
- Emollients
(pharmacology)
- Eosinophils
(cytology, drug effects, physiology)
- Female
- Humans
- Infant
- Infant Welfare
- Leukocyte Count
- Male
- Nitrates
(blood)
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