Abstract | BACKGROUND: The peritoneal equilibration test (PET) is a useful assessment of peritoneal function in continuous ambulatory peritoneal dialysis ( CAPD) patients. However, the natural course of longitudinal change in peritoneal transport is not well defined. PATIENTS: We studied 105 unselected CAPD patients. Average age at enrollment was 50.7 +/- 11.3 years. METHODS: RESULTS: The PET was repeated in 64 patients, of whom 35 were male and 9 had diabetes. The change in D/P over two years was represented as AD/P. No significant change in peritoneal transport was seen after two years (D/P: 0.56 +/- 0.12 vs 0.55 +/- 0.13). A centripetal pattern of change in D/P was observed. The deltaD/P had normal distribution and was inversely correlated with D/P at baseline (r = -0.427, p < 0.005). Both results suggest a regression-to-mean phenomenon. The deltaD/P had no significant correlation with the total number of peritonitis episodes (Spearman r = 0.052, p = 0.74), but after severe peritonitis, affected patients had higher deltaD/P than patients who experienced no severe infection (0.040 +/- 0.136 vs -0.032 +/- 0.120, p < 0.05). For patients with no episodes of severe peritonitis (n = 47), deltaD/P was weakly correlated with baseline TGFbeta level (r = -0.506, p < 0.01). No correlation was seen between the levels of other fibrosing factors and change in peritoneal transport. CONCLUSIONS: Our findings suggest that the centripetal change of peritoneal transport probably reflects a regression-to-mean phenomenon. Peritoneal transport increases after severe peritonitis. The role of TGFbeta levels in PDE with regard to longitudinal change in peritoneal transport requires further study.
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Authors | T Y Wong, C C Szeto, K B Lai, C W Lam, K N Lai, P K Li |
Journal | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
(Perit Dial Int)
2000 Nov-Dec
Vol. 20
Issue 6
Pg. 679-85
ISSN: 0896-8608 [Print] United States |
PMID | 11216559
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Platelet-Derived Growth Factor
- Transforming Growth Factor beta
- Epidermal Growth Factor
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Topics |
- Adolescent
- Adult
- Aged
- Epidermal Growth Factor
(metabolism)
- Female
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Peritoneal Dialysis, Continuous Ambulatory
- Peritoneum
(metabolism, physiopathology)
- Peritonitis
(metabolism)
- Platelet-Derived Growth Factor
(metabolism)
- Transforming Growth Factor beta
(metabolism)
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