Abstract | BACKGROUND: METHODS: Miniswine underwent subtotal (90%) left circumflex coronary stenosis. Baseline positron emission tomography and dobutamine stress echocardiography were performed to document hibernating myocardium in the left circumflex coronary artery distribution. Animals were then randomized to sham redo- thoracotomy (n = 5) or TMR using a holmium:YAG (n = 5), CO2 (n = 5) or excimer (n = 5) laser. Six months postoperatively, the positron emission tomography and dobutamine stress echocardiography studies were repeated and the animals sacrificed. RESULTS: In animals undergoing TMR with holmium: YAG and CO2 lasers, a significant improvement in myocardial blood flow to the lased left circumflex regions was seen. No significant change in myocardial blood flow was seen in sham- or excimer-lased animals. There was a significant improvement in regional stress function of the lased segments 6 months postoperatively in animals undergoing holmium:YAG and CO2 laser TMR that was consistent with a reduction in ischemia. There was no change in wall motion in sham- or excimer-lased animals. Significantly greater neovascularization was observed in the holmium:YAG and CO2 lased regions than with either the sham procedure or excimer TMR. CONCLUSIONS:
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Authors | G C Hughes, A P Kypson, B H Annex, B Yin, J D St Louis, S S Biswas, R E Coleman, T R DeGrado, C L Donovan, K P Landolfo, J E Lowe |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 70
Issue 2
Pg. 504-9
(Aug 2000)
ISSN: 0003-4975 [Print] Netherlands |
PMID | 10969671
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Carbon Dioxide
- Yttrium
- Aluminum
- Holmium
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Topics |
- Aluminum
- Animals
- Carbon Dioxide
- Holmium
- Laser Therapy
- Lasers
- Male
- Myocardial Revascularization
- Myocardial Stunning
(pathology)
- Neovascularization, Physiologic
- Swine
- Tomography, Emission-Computed
- Yttrium
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