Dose-dependent neuroprotection with tiagabine in a focal cerebral ischemia model in rat.

Abstract

Enhancement of the inhibitory activity of GABA may protect ischemic neurons. We evaluated the neuroprotective effect of tiagabine, a novel GABA agonist, in reversible focal cerebral ischemia rats subjected to 2h middle cerebral artery (MCA) occlusion. Tiagabine was given at 10, 20 and 40 mg/kg, i.p., 2 h after the onset of reperfusion. We found that post-ischemia treatment with tiagabine improved neurobehavioral outcome and reduced brain infarction volume in a dose-dependent manner. The data suggest that post-ischemic administration of tiagabine is neuroprotective in the focal cerebral ischemia model.

• Authors: Y Yang, Q Li, C X Wang, T Jeerakathil, A Shuaib
• Journal: Neuroreport (Neuroreport) Vol. 11 Issue 10 Pg. 2307-11 (Jul 14 2000) ISSN: 0959-4965 [Print] England
• PMID: 10923691 (Publication Type: Journal Article)

Chemical References

• GABA Agonists
• Neuroprotective Agents
• Nipecotic Acids
• Tiagabine

Topics

• Animals
• Brain (pathology)
• Cerebral Infarction (pathology, prevention & control)
• Disease Models, Animal
• GABA Agonists (pharmacology)
• Intracranial Embolism (pathology, physiopathology, prevention & control)
• Ischemic Attack, Transient (pathology, physiopathology, prevention & control)
• Male
• Middle Cerebral Artery
• Neuroprotective Agents (pharmacology)
• Nipecotic Acids (pharmacology)
• Rats
• Rats, Wistar
• Tiagabine